SRP3089
IL-22 human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Sinónimos:
IL-TIF
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.32
Productos recomendados
origen biológico
human
recombinante
expressed in E. coli
Ensayo
≥98% (HPLC)
≥98% (SDS-PAGE)
Formulario
lyophilized
mol peso
32.8 kDa
envase
pkg of 10 μg
técnicas
cell culture | mammalian: suitable
impurezas
<0.1 EU/μg endotoxin, tested
color
white to off-white
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
human ... IL22(50616)
Descripción general
IL22 (interleukin 22) is a member of the IL10 related cytokine family, and this gene is localized to the human chromosome 12q15. This protein is predominantly produced by activated CD4+ T cells, and its target cells include mesangial, neuronal and hepatoma cell types. Recombinant human IL-22 is a 33.6 kDa non-disulfide-linked homodimeric protein containing of two 147 amino acid polypeptide chains.
Acciones bioquímicas o fisiológicas
IL22 (interleukin 22) is responsible for eliciting acute-phase responses including, anemia, weight loss, increase in platelet numbers, elevated serum amyloid A and fibrinogen levels and reduced levels serum albumin levels. During inflammation, this protein leads to an increase in pancreatitis-associated protein 1 (PAP1) and osteopontin in pancreatic acinar cells, which might either have protective or trophic effects. This protein is involved in the crosstalk between keratinocytes and inflammatory cells. It is linked with tumorigenesis and progression of tumors. 429 C/T polymorphism in this gene is linked with susceptibility to bladder cancer. In patients with recurrent pregnancy loss, the expression of IL22 is reduced in the uterine decidua, which might lead to disruption of decidual homeostasis, and hence, early loss of pregnancy.
Secuencia
MAPISSHCRL DKSNFQQPYI TNRTFMLAKE ASLADNNTDV RLIGEKLFHG VSMSERCYLM KQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQKLKDTV KKLGESGEIK AIGELDLLFM SLRNACI
Forma física
Lyophilized from 10 mM NaCitrate, pH 3.0
Reconstitución
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.5-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Expression of interleukin-22 in decidua of patients with early pregnancy and unexplained recurrent pregnancy loss.
O'Hern Perfetto C, et al.
Journal of Assisted Reproduction and Genetics, 32(6), 977-984 (2015)
Regulation of T cells and cytokines by the interleukin-10 (IL-10)-family cytokines IL-19, IL-20, IL-22, IL-24 and IL-26.
Oral HB, et al.
European Journal of Immunology, 36(2), 380-388 (2006)
Tao Zhao et al.
Clinics (Sao Paulo, Brazil), 70(10), 686-690 (2015-11-26)
The cytokine interleukin-22 (IL-22), which is produced by T cells and natural killer cells, is associated with tumorigenesis and tumor progression in cancers. However, the role of IL-22 in bladder cancer has not been investigated. A prospective hospital-based case-control study
Sergei V Kotenko
Cytokine & growth factor reviews, 13(3), 223-240 (2002-12-19)
Five novel cytokines (IL-19, IL-20, IL-22 (IL-TIF), IL-24 (human MDA-7, mouse FISP, rat C49A/Mob-5), and IL-26 (AK155)) demonstrating limited primary sequence identity and probable structural homology to IL-10 have been identified. These cellular cytokines, as well as several cytokines encoded
María J Loera-Arias et al.
Biotechnology letters, 36(12), 2489-2494 (2014-09-13)
Interleukin-22 (IL-22) participates in the modulation of innate immunity and inflammation. This cytokine has important therapeutic potential, such as with ulcerative colitis, liver and lung injury, and infection, in different animal models. We generated a Lactococcus lactis strain that secretes
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