SRP2102

TNFα, low endotoxin, His tagged human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

• Sinónimos: DIF, TNF-alpha, TNFA, TNFSF2
• Código UNSPSC: 12352200
• NACRES: NA.26

Propiedades

• origen biológico: human
• recombinante: expressed in E. coli
• Análisis: ≥80% (SDS-PAGE)
• formulario: frozen liquid
• mol peso: ~21 kDa
• envase: pkg of 10 μg
• condiciones de almacenamiento: avoid repeated freeze/thaw cycles
• concentración: 1250 μg/mL
• color: clear colorless
• Nº de acceso NCBI: NM_000594
• Nº de acceso UniProt: P01375
• Condiciones de envío: dry ice
• temp. de almacenamiento: −70°C
• Información sobre el gen: human ... TNF(7124)

Descripción

Descripción general

Tumor necrosis factor α (TNFα or TNFSF2) is encoded by the gene mapped to human chromosome 6p21.33.

Acciones bioquímicas o fisiológicas

Tumor necrosis factor α (TNFα or TNFSF2) is produced by many different cell types including activated monocytes, fibroblasts, endothelial cells, macrophages, T-cells, B-lymphocytes, granulocytes, smooth muscle cells, eosinophilis, chondrocytes and other cell types. It functions as a cytokine involved in cell proliferation, differentiation, apoptosis, lipid metabolism and coagulation. High level of TNFα leads to the development of inflammatory responses that are hallmarks of many diseases including autoimmune diseases, insulin resistance and cancer. The active form of TNFα (18 kDa) is generated by the cleavage of an Ala-Val bond between residues 76-77 of the precursor protein.

Forma física

Clear and colorless frozen liquid solution

Nota de preparación

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable