SRP0706

KAT5 (TIP60), Active

recombinant

• Código UNSPSC: 12352202

Propiedades

• recombinante: expressed in baculovirus infected Sf9 cells
• Análisis: 70-95% (SDS-PAGE)
• formulario: frozen liquid
• actividad específica: 25-35 nmol/min·mg (radiometric)
• mol peso: ~88 kDa
• concentración: 0.1 μg/μL
• nº de acceso: NM_006388
• Condiciones de envío: dry ice
• temp. de almacenamiento: −70°C
• Información sobre el gen: human ... KAT5(10524)

Descripción

Aplicación

Useful for acetyltransferase assay.

Acciones bioquímicas o fisiológicas

Full-length recombinant human KAT5 was expressed by Baculovirus in Sf9 insect cells using an N-terminal GST tag. KAT5 or K (lysine) acetyltransferase 5 is a signaling protein that belongs to the MYST family of histone acetyl transferases (HATs). KAT5 was originally isolated as an HIV-1 TAT-interactive protein that plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins ⁽¹⁾. KAT5 protein is a histone acetylase that is involved in DNA repair and apoptosis and plays an important role in signal transduction. KAT5 acts as a cofactor of TAT that is involved in the regulation of HIV gene expression. KAT5 is also a co-regulator of transcription factors that either promote or suppress tumorigenesis ⁽²⁾.

Reconstitución

Formulated in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.

Almacenamiento y estabilidad

Store in aliquots at -70°C. Avoid freeze/thaw cycles.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable