SRP0570

5′-NUCLEOTIDASE/CD73, His-Tag

recombinant, expressed in HEK 293 cells

• Sinónimos: 5′- nucleotidase, Ecto-5′-nucleotidase
• Código UNSPSC: 12352202
• NACRES: NA.26

Propiedades

• recombinante: expressed in HEK 293 cells
• Formulario: frozen liquid
• mol peso: 58.6 kDa
• Nº de acceso UniProt: P21589
• Condiciones de envío: dry ice
• temp. de almacenamiento: −70°C
• Información sobre el gen: human ... NT5E(4907)

Descripción

Descripción general

5′-Nucleotidase/CD73 is glycosyl-phosphatidyl inositol (GPI)- anchored cell surface protein. Itis present in various tissues and cells including endothelial cells, epithelialcells, and subsets of B and T cells.

Aplicación

5′-Nucleotidase/CD73 has been used as a standard in recombinanthuman CD73 assay.

Acciones bioquímicas o fisiológicas

5′-Nucleotidase/CD73 actsas a rate-limiting enzyme to produce adenosine. It helps in upholding tissuehomeostasis by converting the adenosine triphosphate (ATP)-triggered immuneactivation to adenosine-mediated immunosuppression.CD73 is a novel immunoinhibitory protein that participates in tumor growthand metastasis. CD73 in combination with conventional therapy and/or otherimmune checkpoint inhibitors has been reported to show therapeutic effectsagainst cancer.

Forma física

Aqueous solution

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319
• Consejos de prudencia: P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2
• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable