SML3747

IM1761092 hydrochloride

≥98% (HPLC)

• Sinónimos: IM 1092 hydrochloride, IM 1761092 hydrochloride, IM-1092 hydrochloride, IM-1761092 hydrochloride, IM1092 hydrochloride, N-1-(3-chloro-4-iodo)phenethylbiguanide hydrochloride
• Fórmula empírica (notación de Hill): C₁₀H₁₃ClIN₅·HCl
• Número de CAS: 1820014-33-2
• Peso molecular: 402.06
• Código UNSPSC: 12352200
• NACRES: NA.21

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: white to beige
• solubilidad: H₂O: 2 mg/mL, clear
• temp. de almacenamiento: room temp
• cadena SMILES: ClC1=CC(CCNC(NC(N)=N)=N)=CC=C1I.Cl
• Clave InChI: NSBWTYOKPDFWFE-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

Biguanide-based mammalian respiratory complex I inhibitor that exhibits significantly higher potency than metformin and phenformin.

IM1761092 (IM1092) is a biguanide-based mammalian respiratory complex I inhibitor that reduces cellular oxygen consumption (IC50 = 3.6 μM post 6h treatment; HEPG2 C3A cells) and exhibits significantly higher potency than metformin and phenformin (by 10- to 2000-fold depending on the conditions) using bovine heart mitochondrial membrane preparations (IM1092/phenformin/metformin IC50 = 32 μM/3.8 mM/99 mM against active complex I, 4 μM/131 μM/33 mM against deactive complex I).

Precaución

Hygroscopic

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable