SML3112

cis-22a

≥98% (HPLC)

• Sinónimos: 1-[cis-4-(3-Methylphenyl)cyclohexyl]-4-(3-pyridinyl)piperazine, trifluoroacetate (1:2), cis-1-(4-(3-Methylphenyl)cyclohexyl)-4-((pyridin-4-yl)methyl)piperazine, trifluoroacetate (1:2)
• Fórmula empírica (notación de Hill): C₂₂H₂₉N₃ · 2CF₃CO₂H
• Número de CAS: 1819366-84-1
• Peso molecular: 563.53
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: H₂O: 2 mg/mL, clear
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CC1=CC=CC([C@H]2CC[C@@H](N3CCN(C4=CN=CC=C4)CC3)CC2)=C1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
• Clave InChI: UMKPISXYUQWXJJ-XWOHEVPJSA-N

Descripción

Acciones bioquímicas o fisiológicas

Potent and highly selective TrpV6 (CaT1, ECaC2) inhibitor that selectively inhibits the growth of TrpV6-expressing, but not TrpV6-negative cancer cultures.

cis-22a is a potent and highly selective TrpV6 (CaT1, ECaC2) inhibitor (Cd2⁺ influx IC50 = 320 nM; hTRPV6 transfected HEK293) with much reduced and little potency against other calcium channels and related TRP targets. cis-22a selectively inhibits the growth of TrpV6-expressing breast cancer T47D (IC50 = 25 μM), but not TrpV6-negative ovarian carcinoma SKOV3 cultures (IC50 >50 μM).

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable