SML2170

HX531

≥98% (HPLC)

• Sinónimos: 4-(5H-2,3-(2,5-dimethyl-2,5-hexano)-5-methyl- 8-nitrodibenzo[b,e][1,4]diazepin-11-yl)benzoic acid, 4-(7,8,9,10-Tetrahydro-5,7,7,10.10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]-diazepin-12-yl)-benzoic acid, HX 531, HX-531
• Fórmula empírica (notación de Hill): C₂₉H₂₉N₃O₄
• Número de CAS: 188844-34-0
• Peso molecular: 483.56
• Número MDL: MFCD19690920
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: yellow to orange
• solubilidad: DMSO: 2 mg/mL, clear
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CN(C1=CC2=C(C(C)(CCC2(C)C)C)C=C13)C(C=C4)=C(N=C3C5=CC=C(C=C5)C(O)=O)C=C4[N+]([O-])=O
• InChI: 1S/C29H29N3O4/c1-28(2)12-13-29(3,4)22-16-25-20(15-21(22)28)26(17-6-8-18(9-7-17)27(33)34)30-23-14-19(32(35)36)10-11-24(23)31(25)5/h6-11,14-16H,12-13H2,1-5H3,(H,33,34)
• Clave InChI: SXKPGYKPQPYJER-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

HX-531 is a potent antagonist of the retinoid X receptor (RXR) with an IC50 value of 18 nM. HX531 has been used in many studies of the various effects of retinoids and RXR activity in diseases such as diabetes, Parkinson′s disease, often as a control for agonists such as Bexarotene. It was recently shown to promote white adipogenic differentiation and inhibit both basal and Bexarotene-induced brown adipogenic differentiation.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable