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Merck
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SML2053

Sigma-Aldrich

Lalistat 2

≥98% (HPLC)

Sinónimos:

1-Piperidinecarboxylic acid 4-(1-piperidinyl)-1,2,5-thiadiazol-3-yl ester, Lalistat-2

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About This Item

Fórmula empírica (notación de Hill):
C13H20N4O2S
Número de CAS:
1234569-09-5
Peso molecular:
296.39
Número MDL:
MFCD31544494
Código UNSPSC:
41106300
NACRES:
NA.77

Ensayo

≥98% (HPLC)

Formulario

powder

color

white to beige

solubilidad

DMSO: 2 mg/mL, clear

temp. de almacenamiento

2-8°C

cadena SMILES

O=C(N1CCCCC1)OC2=NSN=C2N3CCCCC3

Clave InChI

PNYYVHOTXOEBEV-UHFFFAOYSA-N

Aplicación

Lalistat 2 has been used as a lysosomal acid lipase (LAL) inhibitor to study its effects on hypoxia-inducible factor (HIF) in mice. It has also been used as a LAL inhibitor to study LAL activity on dried blood spot cards.

Acciones bioquímicas o fisiológicas

Lalistat-2 is a potent and specific competitive inhibitor of the lysosomal acid lipase (LAL/Lipa). Lalistat-2 affects lipid droplets morphology and localization.
potent and specific competitive inhibitor of the lysosomal acid lipase (LAL/Lipa).

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Chloroquine diphosphate salt powder or crystals, 98.5-101.0% (EP)

Sigma-Aldrich

C6628

Chloroquine diphosphate salt

Cloruro de amonio for molecular biology, suitable for cell culture, ≥99.5%

Sigma-Aldrich

A9434

Cloruro de amonio

Maidina Tuohetahuntila et al.
The Journal of biological chemistry, 292(30), 12436-12448 (2017-06-16)
Activation of hepatic stellate cells (HSCs) is a critical step in the development of liver fibrosis. During activation, HSCs lose their lipid droplets (LDs) containing triacylglycerols (TAGs), cholesteryl esters, and retinyl esters (REs). We previously provided evidence for the presence
Chiara Pavanello et al.
Pharmacological research, 147, 104362-104362 (2019-07-23)
Lysosomal acid lipase (LAL) is responsible for the hydrolysis of cholesteryl esters (CE) and triglycerides (TG) within the lysosomes; generated cholesterol and free fatty acids (FFA) are released in the cytosol where they can regulate their own synthesis and metabolism.
Stefanie Schlager et al.
Oncotarget, 8(25), 40037-40051 (2017-04-14)
Degradation of lysosomal lipids requires lysosomal acid lipase (LAL), the only intracellular lipase known to be active at acidic pH. We found LAL to be expressed in murine immune cells with highest mRNA expression in macrophages and neutrophils. Furthermore, we
Anton I Rosenbaum et al.
Journal of medicinal chemistry, 53(14), 5281-5289 (2010-06-19)
Niemann-Pick type C (NPC) disease is a lysosomal storage disorder characterized at the cellular level by abnormal accumulation of cholesterol and other lipids in lysosomal storage organelles. Lysosomal acid lipase (LAL) has been recently identified as a potential therapeutic target
Xinlei Li et al.
Frontiers in cell and developmental biology, 9, 640667-640667 (2021-04-06)
Extracellular vesicles (EVs) are membrane-limited nanoparticles that are liberated by cells and contain a complex molecular payload comprising proteins, microRNA, RNAs, and lipids. EVs may be taken up by other cells resulting in their phenotypic or functional reprogramming. In the
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