SML1560

Azoramide

≥98% (HPLC)

• Sinónimos: N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]-butanamide, N-{2-[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]ethyl} butanamide
• Fórmula empírica (notación de Hill): C₁₅H₁₇ClN₂OS
• Número de CAS: 932986-18-0
• Peso molecular: 308.83
• Número MDL: MFCD08009374
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825964
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (HPLC)
• formulario: powder
• color: white to beige
• solubilidad: DMSO: 30 mg/mL, clear
• temp. de almacenamiento: 2-8°C
• cadena SMILES: ClC1=CC=C(C2=NC(CCNC(CCC)=O)=CS2)C=C1
• InChI: 1S/C15H17ClN2OS/c1-2-3-14(19)17-9-8-13-10-20-15(18-13)11-4-6-12(16)7-5-11/h4-7,10H,2-3,8-9H2,1H3,(H,17,19)
• Clave InChI: VYBFWKKCWTXCQX-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

Azoramide is a modulator of the unfolded protein response with antidiabetic activity. It has dual activity: Azoramide improves endoplasmic reticulum (ER) protein-folding ability and stimulates the expression of ER chaperones that protect cells against ER stress. Azoramide was shown to protect cells from death and dysfunction in multiple models of ER stress. It showed antidiabetic activity in two independent mouse models of obesity by improving insulin sensitivity and protecting pancreatic β cell function against ER stress.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable