SML1555

MS023 hydrochloride

≥98% (HPLC)

• Sinónimos: N1-((4-(4-Isopropoxyphenyl)-1H-pyrrol-3-yl)methyl)-N1-methylethane-1,2-diamine hydrochloride, N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine hydrochloride
• Fórmula empírica (notación de Hill): C₁₇H₂₅N₃O · xHCl
• Número de CAS: 1831110-54-3
• Peso molecular: 287.40 (free base basis)
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825962
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: white to light brown
• solubilidad: H₂O: 20 mg/mL, clear
• temp. de almacenamiento: −20°C
• cadena SMILES: CN(CCN)CC1=CNC=C1C2=CC=C(OC(C)C)C=C2.[H]Cl
• InChI: 1S/C17H25N3O.ClH/c1-13(2)21-16-6-4-14(5-7-16)17-11-19-10-15(17)12-20(3)9-8-18;/h4-7,10-11,13,19H,8-9,12,18H2,1-3H3;1H
• Clave InChI: IEZPALXFXHDDHI-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

MS023 is a potent and selective chemical probe for Type I protein arginine methyltransferases (PRMTs).

MS023 is a potent and selective chemical probe for Type I protein arginine methyltransferases (PRMTs). MS023 is a potent inihbitor of PRMTs 1,3,4,6,and 8 (IC₅₀ = 30, 119, 83, 8, and 8 nM, respectively), which are responsible for asymmetric dimethylation of arginine residues. MS023 is active in cells. For full characterization details, please visit the MS023 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Características y beneficios

MS023 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Otras notas

MS023 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the MS023 probe summary on the Chemical Probes Portal website.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable