SML1532

Cinaciguat hydrochloride

≥98% (HPLC)

• Sinónimos: 4-[((4-Carboxybutyl){2-[(4-phenethylbenzyl)oxy]phenethyl}amino)methyl[benzoic]acid hydrochloride, 4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-benzoic acid hydrochloride, BAY 58-2667 hydrochloride, BAY582667 hydrochloride, UNII-59K0Y58UAD hydrochloride
• Fórmula empírica (notación de Hill): C₃₆H₃₉NO₅ · HCl
• Número de CAS: 646995-35-9
• Peso molecular: 602.16
• Número MDL: MFCD28127267
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825948
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: white to beige
• solubilidad: DMSO: 10 mg/mL, clear
• temp. de almacenamiento: −20°C
• cadena SMILES: OC(C(C=C1)=CC=C1CN(CCCCC(O)=O)CCC2=CC=CC=C2OCC3=CC=C(CCC4=CC=CC=C4)C=C3)=O.[H]Cl
• InChI: 1S/C36H39NO5.ClH/c38-35(39)12-6-7-24-37(26-30-19-21-33(22-20-30)36(40)41)25-23-32-10-4-5-11-34(32)42-27-31-17-15-29(16-18-31)14-13-28-8-2-1-3-9-28;/h1-5,8-11,15-22H,6-7,12-14,23-27H2,(H,38,39)(H,40,41);1H
• Clave InChI: LLHMBJOVHATVSP-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

Cinaciguat activates sGC (soluble guanylate cyclase) independently of NO. Cinaciguat binds to sGC′s NO-sensory H-NOX domain when it is heme-depleted. Also, the compound Cinaciguat protects sGC from oxidation-induced ubiquitin-triggered degradation.

Cinaciguat, also known as BAY 58-2667, is a novel activator of guanylate cyclase. It is used in the treatment of acute decompensated heart failure (ADHF). It has been reported that cinaciguat possesses cardiovascular effects.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable