SML1476

Thiocolchicoside

≥98% (HPLC)

• Sinónimos: (S)-N-[3-(β-D-glucopyranosyloxy)-1,2-dimethoxy-10(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo [a] heptalen-7-yl] acetamide, 2-Demethoxy-2-glucosidoxythiocolchicine
• Fórmula empírica (notación de Hill): C₂₇H₃₃NO₁₀S
• Número de CAS: 602-41-5
• Peso molecular: 563.62
• Número CE: 210-017-7
• Número MDL: MFCD07995056
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825907
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (HPLC)
• formulario: powder
• actividad óptica: [α]/D -510 to -610°, c = 0.5 in H₂O
• color: light yellow to dark yellow
• solubilidad: H₂O: 10 mg/mL, clear
• temp. de almacenamiento: −20°C
• cadena SMILES: O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC(CC[C@H](NC(C)=O)C(C3=CC=C4SC)=CC4=O)=C3C(OC)=C2OC)[C@@H]1O
• InChI: 1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,19+,22+,23-,24+,27+/m0/s1
• Clave InChI: LEQAKWQJCITZNK-AXHKHJLKSA-N

Descripción

Acciones bioquímicas o fisiológicas

Thiocolchicoside acts as a muscle relaxant. In experimental animals, thiocolchicoside results in malfunctions (teratogenic) and impairs chromosomes. It is advised to be used as an analgesic for patients with muscle pain, starting with paracetamol. Thiocolchicoside can be used in irrigation solution at the time of endoscopic treatment of ureteral calculus to reduce the movement of stones.

Thiocolchicoside is a potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist with muscle relaxant, anti-inflammatory, and analgesic activity. Thiocolchicoside has also been found to suppress nuclear factor kappa B ligand (RANKL) activation of NF-KB resulting in suppression of osteoclastogenesis.

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H301,H341,H361fd,H372
• Consejos de prudencia: P201 - P301 + P310 + P330
• Clasificaciones de peligro: Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1
• Órganos de actuación: Gastro-intestinal system
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable