SML1259

GSK2194069

≥97% (HPLC)

• Sinónimos: (S)-4-(4-(Benzofuran-5-yl)phenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5(4H)-one
• Fórmula empírica (notación de Hill): C₂₅H₂₄N₄O₃
• Número de CAS: 1332331-08-4
• Peso molecular: 428.48
• Número MDL: MFCD28167807
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825751
• NACRES: NA.77

Propiedades

• Análisis: ≥97% (HPLC)
• formulario: powder
• color: white to light brown
• solubilidad: DMSO: 5 mg/mL, clear (warmed)
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C(C1CC1)N2CC[C@@H](CC(N3C4=CC=C(C5=CC=C(OC=C6)C6=C5)C=C4)=NNC3=O)C2
• InChI: 1S/C25H24N4O3/c30-24(18-1-2-18)28-11-9-16(15-28)13-23-26-27-25(31)29(23)21-6-3-17(4-7-21)19-5-8-22-20(14-19)10-12-32-22/h3-8,10,12,14,16,18H,1-2,9,11,13,15H2,(H,27,31)/t16-/m0/s1
• Clave InChI: AQTPWCUIYUOEMG-INIZCTEOSA-N

Descripción

Acciones bioquímicas o fisiológicas

GSK2194069 is a fatty acid synthase (FAS) inhibitor. GSK2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS with an IC₅₀ of 7.7 ± 4.1 nM for the overall hFAS reaction. FAS is upregulated in some cancers, including prostate cancer. GSK2194069 was found to inhibit tumour growth in prostate cancer C42b cell xenografts generated in Nod-SCID-gamma mice. Cellular FAS inhibition reduced cell growth were also demonstrated in non-small-cell lung (A549) cancer cell lines with an average EC₅₀ of 15 ± 0.5 nM.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable