SML1209

OICR-9429

≥98% (HPLC)

• Sinónimos: 6-Oxo-4-trifluoromethyl-1,6-dihydro-pyridine-3-carboxylic acid [4-(4-methyl-piperazin-1-yl)-3′-morpholin-4-ylmethyl-biphenyl-3-yl]-amide
• Fórmula empírica (notación de Hill): C₂₉H₃₂F₃N₅O₃
• Número de CAS: 1801787-56-3
• Peso molecular: 555.59
• Número MDL: MFCD18364451
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825720
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (HPLC)
• formulario: powder
• color: white to light brown
• solubilidad: DMSO: 10 mg/mL, clear
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C7H5FN2O2/c1-2-3-10-4-5(8)6(11)9-7(10)12/h1,4H,3H2,(H,9,11,12)
• Clave InChI: GMCOGJQJFDQZCP-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

OICR-9429 is a cell penetrant, potent and selective antagonist of the interaction of WDR5 (WD repeat domain 5) with peptide regions of MLL and Histone 3 that potently binds to WDR5. OICR-9429 inhibits the interaction of WDR5 with MLL1 and RbBP5 in cells. For full characterization details, please see OICR-9429 on the Structural Genomics Consortium (SGC) website.

OICR-0547 is the negative control for the active probe, OICR-9429. To request a sample of the negative control from the SGC, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Características y beneficios

OICR-9429 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Otras notas

OICR-9429 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the OICR-9429 probe summary on the Chemical Probes Portal website.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315
• Consejos de prudencia: P264 - P280 - P302 + P352 - P332 + P313 - P362 + P364
• Clasificaciones de peligro: Skin Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable