SML0801

Palomid 529

≥98% (HPLC)

• Sinónimos: 8-(1-Hydroxyethyl)-2-methoxy-3-((4-methoxybenzyl)oxy)-6H-benzo[c]chromen-6-one, 8-(1-Hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methoxy]-6H-dibenzo[b,d]pyran-6-one, P529, SG 00529
• Fórmula empírica (notación de Hill): C₂₄H₂₂O₆
• Número de CAS: 914913-88-5
• Peso molecular: 406.43
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (HPLC)
• formulario: powder
• color: white to beige
• solubilidad: DMSO: 10 mg/mL, clear
• temp. de almacenamiento: −20°C
• InChI: 1S/C24H22O6/c1-14(25)16-6-9-18-19-11-22(28-3)23(12-21(19)30-24(26)20(18)10-16)29-13-15-4-7-17(27-2)8-5-15/h4-12,14,25H,13H2,1-3H3
• Clave InChI: YEAHTLOYHVWAKW-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

Palomid 529 (P529) is a PI3K/Akt/mTOR inhibitor, which is unique in that it causes the dissociation of both the TORC1 and TORC2 complexes and inhibits both Akt and mTOR signaling. Palomid 529 has been shown to inhibit tumor growth, angiogenesis, and vascular permeability. Palomid 529 (P529) inhibited glioblastoma growth, penetrating the blood brain barrier with little affinity for ATP-binding cassette (ABC) drug efflux transporters ABCB1 and ABCG2. Palomid 529 has also shown promise as a possible treatment for macular degeneration and keloid disease.

Características y beneficios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H301
• Consejos de prudencia: P264 - P270 - P301 + P310 - P405 - P501
• Clasificaciones de peligro: Acute Tox. 3 Oral
• Código de clase de almacenamiento: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable