SML0510

S 26948

≥98% (HPLC)

• Sinónimos: 2-[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-propanedioic acid 1,3-dimethyl ester, S26948
• Fórmula empírica (notación de Hill): C₂₈H₂₅NO₇S
• Número de CAS: 353280-43-0
• Peso molecular: 519.57
• Número MDL: MFCD18086885
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825519
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: DMSO: 10 mg/mL (clear solution)
• temp. de almacenamiento: 2-8°C
• cadena SMILES: COC(=O)C(Cc1ccc(OCCN2C(=O)Sc3cc(ccc23)C(=O)c4ccccc4)cc1)C(=O)OC
• InChI: 1S/C28H25NO7S/c1-34-26(31)22(27(32)35-2)16-18-8-11-21(12-9-18)36-15-14-29-23-13-10-20(17-24(23)37-28(29)33)25(30)19-6-4-3-5-7-19/h3-13,17,22H,14-16H2,1-2H3
• Clave InChI: NSMJEHGOMXSLCW-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

S 26948 belongs to the non-thiazolidinedione (TZD) class of drugs. It has the potential to treat diabetes and atherogenesis.

S 26948 is a partial PPARγ agonist; selective PPARγ modulator (SPPARγM).

S 26948 is a selective PPARγ modulator (SPPARγM). S 26948 is as effective as rosiglitazone in reducing insulin resistance and lipid homeostasis, but does not increase body or white adipose tissue weight. S 26948 also leads to different co-activatior recruitment to PPARγ than rosiglitazone.

Características y beneficios

This compound is featured on the Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable