SML0420

TAPI-2 acetate salt

≥98% (HPLC)

• Sinónimos: N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-t-butyl-glycine-L-alanine 2-aminoethyl amide, Tumor necrosis factor-α protease inhibitor-2, TNF-α protease inhibitor-2
• Fórmula empírica (notación de Hill): C₁₉H₃₇N₅O₅ · xC₂H₄O₂
• Número de CAS: 689284-12-6
• Peso molecular: 415.53 (free base basis)
• Número MDL: MFCD22666396
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825415
• NACRES: NA.77

Propiedades

• Análisis: ≥98% (HPLC)
• formulario: lyophilized powder
• color: white to off-white
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• cadena SMILES: CC(O)=O.CC(C)C[C@H](CC(=O)NO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)NCCN)C(C)(C)C
• InChI: 1S/C19H37N5O5.C2H4O2/c1-11(2)9-13(10-14(25)24-29)17(27)23-15(19(4,5)6)18(28)22-12(3)16(26)21-8-7-20;1-2(3)4/h11-13,15,29H,7-10,20H2,1-6H3,(H,21,26)(H,22,28)(H,23,27)(H,24,25);1H3,(H,3,4)/t12-,13+,15+;/m0./s1
• Clave InChI: LMUSZKBIFGOFBD-RAFLFFCLSA-N

Descripción

Aplicación

TAPI-2 acetate salt has been used to inhibit protease activity in HepG2 cells.

Acciones bioquímicas o fisiológicas

TAPI-2 is a potent inhibitor matrix metalloproteinases and TACE (TNF-α convertase/ADAM17/α-secretase). It blocks the shedding of several cell surface proteins such as β-amyloid precursor protein, inhibits TNF-α release as well as a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands. TAPI-2 is considered a fairly broad metalloproteinase inhibitor, but it much more selective for TACE than GM6001.

Características y beneficios

This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable