SMB01000

Grandiflorenic acid

≥90% (LC/MS-ELSD)

• Sinónimos: (4S,5R,9R)-5,9-Dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadec-10-ene-5-carboxylic acid, Kaura-9(11),16-dien-18-oic acid
• Fórmula empírica (notación de Hill): C₂₀H₂₈O₂
• Número de CAS: 22338-67-6
• Peso molecular: 300.44
• Número MDL: MFCD23103740
• Código UNSPSC: 12352205
• NACRES: NA.25

Propiedades

• origen biológico: plant
• Ensayo: ≥90% (LC/MS-ELSD)
• Formulario: solid
• mol peso: 300.44
• solubilidad: water: slightly soluble
• aplicaciones: metabolomics; vitamins, nutraceuticals, and natural products
• temp. de almacenamiento: −20°C
• cadena SMILES: OC(=O)[C@]1([C@@H]2[C@@](CCC1)(C3=CCC4CC3(CC2)CC4=C)C)C
• InChI: 1S/C20H28O2/c1-13-11-20-10-7-15-18(2,16(20)6-5-14(13)12-20)8-4-9-19(15,3)17(21)22/h6,14-15H,1,4-5,7-12H2,2-3H3,(H,21,22)/t14?,15-,18+,19+,20?/m0/s1
• Clave InChI: RJIPNPHMQGDUBW-MZWQVCBVSA-N

Descripción

Descripción general

Grandiflorenic acid, a diterpenoid, is a natural product commonly derived from Wedelia trilobata, Sphagneticola trilobata and Siegesbeckia orientalis L. It exhibits various biological activities such as anti-inflammatory, anti-depressant, anti-fertility, and anti-microbial properties.

Aplicación

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Acciones bioquímicas o fisiológicas

Grandiflorenic acid exhibits antibacterial, anti-inflammatory, antileishmanial and wound-healing properties.
Grandiflorenic acid shows moderate cytotoxic (IC50 15μM in RAW264.7 cells) and antiplasmodial activities (IC50 23μM against P. falciparum).

Grandiflorenic acid (GFA) shows promise as an anticancer agent by inhibiting cell proliferation and reducing cell size in breast (MCF7), lung (A549), and liver (HuH7.5) tumor cell lines. Further, it also shows effects on uterine motility throughout the estrus cycle suggesting it may have antifertility properties, possibly by affecting hormones and adrenergic pathways in the uterus.

Características y beneficios

• High quality compound suitable for multiple research applications
• Compatible with HPLC and mass spectrometry techniques

Otras notas

For additional information on our range of Biochemicals, please complete this form.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable