SCP0224
Prostate Specific Antigen Substrate
≥95% (HPLC), lyophilized
Sinónimos:
KLK3, Kallikrein-related peptidase-3, PSA
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About This Item
Fórmula empírica (notación de Hill):
C44H64N12O13
Peso molecular:
969.05
Código UNSPSC:
12352204
NACRES:
NA.32
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Nombre del producto
Prostate Specific Antigen Substrate,
Ensayo
≥95% (HPLC)
Formulario
lyophilized
composición
Peptide Content, ≥75%
condiciones de almacenamiento
protect from light
temp. de almacenamiento
−20°C
Amino Acid Sequence
Mu-His-Ser-Ser-Lys-Leu-Gln-AMC
Descripción general
Prostate specific antigen (PSA) is a kallikrein-related serine peptidase that belongs to the chymotrypsin subfamily serine protease. It was originally found in human semen. PSA is also detected in serum correlated to benign and metastatic disease.
Aplicación
Prostate Specific Antigen Substrate has been used to assay recombinant severe acute respiratory syndrome coronavirus-2 viral 3-chymotrypsin-like cysteine protease (SARS-CoV-2 3CLpro).
Acciones bioquímicas o fisiológicas
Prostate specific antigen (PSA). It exhibits chymotrypsin-like activity. PSA is the most abundant protease found in the prostate and secreted into the seminal fluid. It is a useful biomarker for prostate cancer. PSA digests the gel-forming proteins semenogelins I and II in semen. It shows antiangiogenic activity in vitro and in vivo.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Journal of medicinal chemistry, 65(4), 2956-2970 (2021-11-04)
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The emergence of SARS-CoV-2 in late 2019, and the subsequent COVID-19 pandemic, has led to substantial mortality, together with mass global disruption. There is an urgent need for novel antiviral drugs for therapeutic or prophylactic application. Cathepsin L is a
Johanna M Mattsson et al.
PloS one, 9(9), e107819-e107819 (2014-09-23)
Prostate-specific antigen (PSA or kallikrein-related peptidase-3, KLK3) exerts chymotrypsin-like proteolytic activity. The main biological function of PSA is the liquefaction of the clot formed after ejaculation by cleavage of semenogelins I and II in seminal fluid. PSA also cleaves several
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