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SBR00031

Sigma-Aldrich

MIT HCl Ready Made Solution

(10 mg MIT/mL)

Sinónimos:

2-Methyl-1,2-thiazol-3-one, Methylisothiazolinone HCl, Methylisothiazolinone hydrochloride

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About This Item

Código UNSPSC:
51102829
NACRES:
NA.76

Formulario

liquid

Nivel de calidad

200

concentración

(10 mg MIT/mL)
1%

Modo de acción

protein synthesis | interferes

temp. de almacenamiento

2-8°C

InChI

1S/C4H5NOS.ClH/c1-5-4(6)2-3-7-5;/h2-3H,1H3;1H

Clave InChI

SJXPQSRCFCPWQQ-UHFFFAOYSA-N

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Descripción general

Methylisothiazolinone, also known as 2-Methyl-4-isothiazolin-3-one, belongs to the group of isothiazolinones. 2-Methyl-4-isothiazolin-3-one is utilized in cell biology and biochemical applications to effectively prevent the growth of bacterial contaminants, ensuring the purity of cell lines.

Aplicación

Methylisothiazolinone (MIT) has been used:
  • in research on the effects of the N-methyl D-aspartate (NMDA) receptor antagonist kynurenic acid on human cortical development
  • as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and its role in apoptotic cell death
  • to research the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites

Acciones bioquímicas o fisiológicas

Mode of Action: Inhibits the growth of microorganisms by disrupting the normal function of microbial cells and interfering with essential cellular processes

Características y beneficios

  • Ready available solution reduce the need for preparation time
  • Commonly used in Cell Biology and Biochemical applications
  • High quality antibiotic suitable for mulitple research applications

Otras notas

For additional information on our range of Biochemicals, please complete this form.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H315,H317,H319,H412

Clasificaciones de peligro

Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Shen Du et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(17), 7408-7416 (2002-08-28)
Neurodegenerative disorders in humans may be triggered or exacerbated by exposure to occupational or environmental agents. Here, we show that a brief exposure to methylisothiazolinone, a widely used industrial and household biocide, is highly toxic to cultured neurons but not
Zhengxi Wei et al.
Toxicology letters, 338, 67-77 (2020-12-09)
Chemical-peptide conjugation is the molecular initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatography/ultraviolet (HPLC/UV) detection method to quantify chemical-peptide conjugation in a direct peptide reactivity assay (DPRA), which measures the depletion of two synthetic
Eun-Jung Park et al.
Toxicology in vitro : an international journal published in association with BIBRA, 62, 104661-104661 (2019-10-21)
Methylisothiazolinone (MIT) has been used in wide spectrum of fields due to its ability to inhibit microbial proliferation with low toxicity. Meanwhile, in Korea, the concern about the hazardous effects of MIT was amplified by the occurrence of patients that

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