SAB5700429

Anti-Phospho-BCR-Y177 antibody produced in rabbit

• Sinónimos: ALL, BCR, BCR1, CML, D22S11, D22S662, PHL
• Código UNSPSC: 12352203
• NACRES: NA.41
• clon: polyclonal
• application: WB
• reactividad de especies: mouse, human
• técnicas: western blot: 1:500-1:2000

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: 137; 142
• reactividad de especies: mouse, human
• concentración: 2.66 mg/ml
• técnicas: western blot: 1:500-1:2000
• Nº de acceso UniProt: P11274
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: phosphorylation (pTyr177)
• Información sobre el gen: human ... BCR(613)

Descripción

Descripción general

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Inmunógeno

A synthetic phosphorylated peptide around Y177 of human BCR (NP_004318.3).

Forma física

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Almacenamiento y estabilidad

Store at -20℃. Avoid freeze / thaw cycles.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable