SAB5500047
Anti-CD19 antibody, Rabbit monoclonal
clone SP110, recombinant, expressed in proprietary host, affinity isolated antibody
Sinónimos:
Anti-B4, Anti-CVID3
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Productos recomendados
origen biológico
rabbit
Nivel de calidad
recombinante
expressed in proprietary host
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
SP110, monoclonal
reactividad de especies
human (tested)
técnicas
flow cytometry: 1:100
immunohistochemistry: 1:200
isotipo
IgG
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
2-8°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... CD19(930)
Descripción general
CD19 (cluster of differentiation 19) is a 95 kDa protein localized on the surface of nearly all B lymphocytes and is considered to be the specific surface marker for B cells. This protein belongs to the immunoglobulin (Ig) superfamily with a cytoplasmic region of ∼240 amino acids and is involved in the regulation of B cell function. The gene encoding CD19 is localized on human chromosome 16p11.2.
CD19 is expressed in B lymphocytes and B-cell lymphoma. It may also be present on some early myeloid progenitors, particularly those of the monoblastic type. It appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. CD19 is negative in T lymphocytes, plasma cells, and their tumors.
Inmunógeno
Synthetic peptide corresponding to C-terminus of human CD19.
Acciones bioquímicas o fisiológicas
CD19 (cluster of differentiation 19) expression is restricted to normal and malignant B-lineage cells. Therefore, it is considered to be a striking target for immunotherapies aimed at B-cell malignancies. CD19 helps B lymphocytes to initiate primary immune response even at low concentrations of antigen. The encoded protein plays a crucial role in initiating intrinsic B cell signaling thresholds by regulating both B cell receptor (BCR)-dependent and independent signaling. It also functions as a biomarker for B-cell development.
Características y beneficios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forma física
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells.
Kochenderfer JN, et al.
Blood (2011)
The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity.
Fearon DT and Carter RH
Annual Review of Immunology, 13(1), 127-149 (1995)
Aleksandra Georgievski et al.
Cell death & disease, 13(4), 337-337 (2022-04-14)
Patient-derived xenografted (PDX) models were generated through the transplantation of primary acute lymphoblastic leukemia (ALL) cells into immunodeficient NSG mice. We observed that ALL cells from mouse bone marrow (BM) produced extracellular vesicles (EVs) with specific expression of inducible heat
Kemeng Wang et al.
Experimental hematology & oncology, 1(1), 36-36 (2012-12-06)
The human CD19 antigen is a 95 kd transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD19 is classified as a type I transmembrane protein, with a single transmembrane domain, a cytoplasmic C-terminus, and extracellular N-terminus. CD19 is a biomarker for
A Pezzutto et al.
Journal of immunology (Baltimore, Md. : 1950), 138(9), 2793-2799 (1987-05-01)
The 95 Kd CD19 antigen is the broadest lineage specific surface marker for B cells: it is present on the surface of virtually all B lymphocytes, including early B progenitor cells. In this study we have evaluated the function of
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