SAB5200113

Anti-Amyloid Precursor Protein (APP) Antibody

rabbit polyclonal

• Sinónimos: Anti-A11, Anti-Amyloid Oligomer αβ, Anti-Amyloid Oligomers (A11)
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• Nombre del producto: Anti-APP antibody produced in rabbit, 1 mg/mL, affinity isolated antibody
• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous glycerol solution
• reactividad de especies: mouse, eukaryotes, rat, human
• concentración: 1 mg/mL
• técnicas: immunohistochemistry: suitable; immunoprecipitation (IP): suitable; indirect ELISA: suitable; indirect immunofluorescence: suitable; western blot: suitable
• Nº de acceso NCBI: NM_000484.2
• Nº de acceso UniProt: P05067
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... APP(351)

Descripción

Descripción general

Amyloid β precursor protein (APP) is a type 1 transmembrane protein. The gene is located on human chromosome 21q21.3.

Especificidad

Recognizes all types of amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.

Inmunógeno

Synthetic molecular mimic of soluble oligomers.

Aplicación

Anti-APP antibody produced in rabbit has been used in western blotting.

Acciones bioquímicas o fisiológicas

Amyloid β precursor protein (APP) regulates cell signaling. Mutation in this gene is associated with Alzheimer′s disease. It is implicated in synaptic plasticity, dendritic morphogenesis and neuroprotection. APP modulates synaptic vesicle proteins and synaptic transmission. It is involved in GABAergic transmission and maintains the excitatory/inhibitory (E/I) balance.

Amyloid precursor protein (APP) plays a key role in Wnt signalling. It helps to increase synaptoxicity, that is facilitated by Dickkopf-1 (Dkk1). Mutations on this gene results in autosomal dominant early-onset Alzheimer disease (ADEOAD)/hereditary dementia with cerebral amyloid angiopathy (CAA).

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

PBS, 50% glycerol, and 0.09% sodium azide

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable