SAB4702062

Monoclonal Anti-HLA-E purified produced in mouse

• Sinónimos: HLA class I histocompatibility antigen, MHC class I antigen E, alpha chain E
• Código UNSPSC: 12352203

Propiedades

• conjugado: unconjugated
• Nivel de calidad: 100
• tipo de anticuerpo: primary antibodies
• clon: MEM-E/02, monoclonal
• Formulario: buffered aqueous solution
• reactividad de especies: ( Non-human primates), human
• concentración: 1 mg/ml
• técnicas: immunohistochemistry: suitable; western blot: suitable
• isotipo: IgG1
• Nº de acceso UniProt: P13747
• temp. de almacenamiento: 2-8°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... HLA-E(3133)

Descripción

Descripción general

HLA-E (human leukocyte antigen E) is a non-classical MHC I antigen, which is important for dialogue with NK cells and their regulation through interaction with CD94/NKG2 receptor. Like other MHC I molecules, transmembrane HLA-E molecule (45 kDa) associates with beta2 microglobulin. Unlike HLA-G, expression of HLA-E molecules is not so restricted, but it has been detected at least at mRNA level in virtually all cells and tissues examined. In peripheral blood, HLA-E protein is expressed at least in all mononuclear cells, but in different quantity (B cells and monocytes more than T cells and NK cells).

Especificidad

The antibody MEM-E/02 specifically reacts with an extracellular epitope on denaturated heavy chain of human HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of all human cell types.

Inmunógeno

Recombinant human HLA-E denaturated heavy chain.

Forma física

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Nota de preparación

Purified by protein-A affinity chromatography.

Almacenamiento y estabilidad

Store at 2-8°C. Do not freeze.

Otras notas

The antibody solution should be gently mixed before use.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable