SAB4702025

Monoclonal Anti-EGFR PE produced in mouse

• Sinónimos: EGF-R, ERBB1, Her1, NISBD2, PIG61
• Código UNSPSC: 12352203

Propiedades

• conjugado: phycoerythrin (R-PE) conjugate
• Nivel de calidad: 100
• tipo de anticuerpo: primary antibodies
• clon: EGFR1, monoclonal
• Formulario: buffered aqueous solution
• reactividad de especies: horse, ( Human)
• técnicas: flow cytometry: suitable
• isotipo: IgG2bκ
• Nº de acceso UniProt: P00533
• temp. de almacenamiento: 2-8°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... EGFR(1956)

Descripción

Descripción general

The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.

Especificidad

The mouse monoclonal antibody EGFR1 reacts with extracellular domain of human protein kinase EGFR (ErbB1 / HER1); epitope within amino acids 6-273.

Inmunógeno

Human epidermoid carcinoma line A431

Forma física

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Nota de preparación

Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Almacenamiento y estabilidad

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Otras notas

The antibody solution should be gently mixed before use.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable