SAB4702005

Monoclonal Anti-c-Myc tag Biotin produced in mouse

• Sinónimos: MRTL, MYCC, bHLH
• Código UNSPSC: 12352203

Propiedades

• conjugado: biotin conjugate
• Nivel de calidad: 100
• tipo de anticuerpo: primary antibodies
• clon: 9E10, monoclonal
• formulario: buffered aqueous solution
• reactividad de especies: ( Human), (Tagged fusion proteins in all species)
• concentración: 1 mg/ml
• técnicas: flow cytometry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• isotipo: IgG1
• Nº de acceso UniProt: P01106
• temp. de almacenamiento: 2-8°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... MYC(4609)

Descripción

Descripción general

The c-myc gene (8q24 on human chromosome) is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. The c-Myc protein is a transcription factor (nuclear localization). c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2 and C-Jun N-terminal Kinase (JNK) in cell proliferation and cell cycle regulation. In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated. c-Myc is also essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells.

Especificidad

The antibody 9E10 can be used to detect the c-Myc tag.

Inmunógeno

Synthetic peptide sequence (AEEQKLISEEDLL) corresponding to the C-terminal region of human c-Myc.

Forma física

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Nota de preparación

Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.

Almacenamiento y estabilidad

Store at 2-8°C. Do not freeze.

Otras notas

The antibody solution should be gently mixed before use.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable