SAB4700637

Monoclonal Anti-HLA Class I, low endotoxin antibody produced in mouse

clone W6/32, purified immunoglobulin, buffered aqueous solution

• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• conjugado: unconjugated
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: W6/32, monoclonal
• formulario: buffered aqueous solution
• reactividad de especies: human
• concentración: 1 mg/mL
• técnicas: flow cytometry: suitable
• impurezas: ≤1 EU/μg endotoxin (LAL test)
• isotipo: IgG2a
• Nº de acceso NCBI: NM_002116.6; NM_002117.4; NM_005514.6
• Nº de acceso UniProt: P04439
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... HLA-A(3105) , HLA-B(3106) , HLA-C(3107)

Descripción

Descripción general

Human leukocyte antigen A classical class I family consists of three members including HLA-A, HLA-B and HLA-C. Members of classical class I major histocompatibility complex (MHC) contain a peptide bound to a transmembrane glycoprotein subunit, the heavy chain, in association with a soluble light chain called β2-microglobulin. Class I MHC molecules are present in changeable volumes on all nucleated cells.

The antibody W6/32 recognises MHC Class I molecules (MHC Class Ia) that are expressed on the surface of all human nucleated cell types. The antibody W6/32 is a valuable reagent for analysing variations in HLA class I expression in different disease states e.g. liver disease, muscular dystrophy, inflammatory myopathy and other neuromuscular disorders.

The previously assigned protein identifier P01891 has been merged into P04439. Full details can be found on the UniProt database.

Inmunógeno

Membrane of human tonsil cells

Aplicación

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2-8 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Acciones bioquímicas o fisiológicas

Human leukocyte antigen A class I downregulation is implicated in tumor invasion and development. Genetic variations in the class I major histocompatibility complex (MHC) is associated with the development of melanoma. HLA-viral peptide interaction plays a major role in the regulation of human immunodeficiency virus (HIV) infection.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Solution in azide free phosphate buffered saline, pH 7.4; 0.2 um filter sterilized. Endotoxin level is less than 0.01 EU/ug of the protein, as determined by the LAL test.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable