SAB4700014
Monoclonal Anti-B2M antibody produced in mouse
clone B2M-02, purified immunoglobulin, buffered aqueous solution
Sinónimos:
Anti-β-2-microglobulin
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
clon:
B2M-02, monoclonal
application:
FACS
reactividad de especies:
human, pig
técnicas:
flow cytometry: suitable
citations:
5
Productos recomendados
origen biológico
mouse
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
B2M-02, monoclonal
Formulario
buffered aqueous solution
reactividad de especies
human, pig
concentración
1 mg/mL
técnicas
flow cytometry: suitable
isotipo
IgG1
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
2-8°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... B2M(567)
Descripción general
β2-microglobulin (B2M) is a non-glycosylated polypeptide composed of 99 amino acids. It is present on the surface of all nucleated cells. The protein is characterized with the single polypeptide chain, which is linked noncovalently to major histocompatibility complex (MHC) class I cell surface antigen. The gene coding for B2M is mapped to human chromosome 15q.
Inmunógeno
Purified isolated human beta2-microglobulin
Aplicación
The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Acciones bioquímicas o fisiológicas
β2-microglobulin (B2M) plays a vital role in cell survival, proliferation and metastasis in various types of cancer. Elevated concentration of β-2-microglobulin (B2M) can be considered as a prognostic marker for hemophagocytic lymphohistiocytosis (HLH). Elevated concentration of circulating B2M, due to renal dysfunction and long term hemodialysis leads to dialysis-related amyloidosis. Overexpression of serum B2M is observed in hepatitis C virus (HCV) related chronic liver diseases, therefore it might act as a potential marker for the HCV disease progression towards cirrhosis and carcinoma. Missense mutation in the B2M gene results in familial hypercatabolic hypoproteinemia (FHH).
Características y beneficios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forma física
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Zoe Hall et al.
The Journal of biological chemistry, 291(9), 4626-4637 (2015-12-15)
β2-Microglobulin (β2m), a key component of the major histocompatibility class I complex, can aggregate into fibrils with severe clinical consequences. As such, investigating the structural aspects of the formation of oligomeric intermediates of β2m and their subsequent progression toward fibrillar
Tiantong Jiang et al.
Disease markers, 2016, 1523959-1523959 (2016-04-26)
To determine the prognostic significance of beta2 microglobulin (β2-m) concentrations in patients with hemophagocytic lymphohistiocytosis (HLH), a rare disorder caused by pathologic activation of the immune system. The study population consisted of 74 patients diagnosed with HLH and 35 healthy
J H Nadeau et al.
Proceedings of the National Academy of Sciences of the United States of America, 81(3), 814-818 (1984-02-01)
Linkage relationships of homologous loci in man and mouse were used to estimate the mean length of autosomal segments conserved during evolution. Comparison of the locations of greater than 83 homologous loci revealed 13 conserved segments. Map distances between the
S M Ouda et al.
Asian Pacific journal of cancer prevention : APJCP, 16(17), 7825-7829 (2015-12-03)
Egypt has the highest prevalence of HCV infection in the world (~14.7%). Around 10-15% of HCV-infected persons will advance to cirrhosis within the first 20 years. The incidence of HCC is expected to grow in the next two decades, largely
Jonghan Kim et al.
Clinical immunology (Orlando, Fla.), 122(2), 146-155 (2006-10-19)
The nonclassical MHC class-I molecule, FcRn, salvages both IgG and albumin from degradation. Here we introduce a mechanism-based kinetic model for human to quantify FcRn-mediated recycling of both ligands based on saturable kinetics and data from the literature using easily
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