SAB4504615

Anti-phospho-LATS1/2 (pThr^1079/1041) antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Anti-WARTS, Anti-wts
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: antigen 126 kDa
• reactividad de especies: mouse, rat, human
• concentración: ~1 mg/mL
• técnicas: ELISA: 1:20000; immunohistochemistry: 1:50-1:100
• Nº de acceso NCBI: O95835; Q9NRM7
• Nº de acceso UniProt: O95835
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: phosphorylation (pThr1079/pThr1041)
• Información sobre el gen: human ... LATS1(9113) , LATS2(26524)

Descripción

Descripción general

Large tumor suppressor kinase 1/ 2 (LATS1/2) is a mammalian homologue of the Drosophila tumor suppressor gene (lats)/warts. LATS1 and LATS2 are encoded by the gene mapped to human chromosomes 6q23-25.1 and 13q11–q12 respectively. hLATS2 is highly expressed in skeletal muscle and heart. LATS1 encodes a putative serine/threonine kinase.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human LATS1/2 around the phosphorylation site of Thr1079/1041.

Immunogen Range: 1041-1090

Acciones bioquímicas o fisiológicas

Large tumor suppressor kinase 1 (LATS1) and LATS2 are the key kinase constituents of the Hippo pathway. They play a vital role in the regulation of tumor progression and cell cycle, via various mechanisms and signaling pathways. LATS1 acts as a tumor suppressor in cervical cancer by regulating the expression of cyclin E, p27, matrix metalloproteinase 9 (MMP9) and yes-associated protein 1 (YAP). Overexpression of LATS2 leads to the development of acute myeloid leukemia (AML). Therefore, it is considered as a potential therapeutic target for AML treatment.

Características y beneficios

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Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable