SAB4504326

Anti-phospho-Vitamin D Receptor (pSer²⁰⁸) antibody produced in rabbit

affinity isolated antibody

• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: antigen 48 kDa
• reactividad de especies: mouse, rat, human
• concentración: ~1 mg/mL
• técnicas: ELISA: 1:10000; immunofluorescence: 1:100-1:500; western blot: 1:500-1:1000
• Nº de acceso NCBI: P11473
• Nº de acceso UniProt: P11473
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: phosphorylation (pSer208)
• Información sobre el gen: human ... VDR(7421)

Descripción

Descripción general

VDR (vitamin D receptor) or vitamin D3 receptor is a member of the steroid and thyroid hormone receptors superfamily of trans-acting transcriptional regulatory factors. It is an intracellular polypeptide of 50-60 kDa. This receptor is composed of a highly conserved cysteine, lysine, and arginine-rich DNA-binding domain, and a hydrophobic ligand-binding domain in its C-terminal. It shares size and sequence similarity to thyroid hormone receptor. VDR gene is localized to human chromosome 12q12-q14.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human Vitamin D Receptor around the phosphorylation site of Ser208.

Immunogen Range: 181-230

Acciones bioquímicas o fisiológicas

VDR (vitamin D receptor) binds with its ligand vitamin D3, and acts upon the target cell nuclei to induce various biological effects. Vitamin D3 is also thought to have immunomodulatory effects, and gene polymorphisms are linked with pertussis. The variants might affect the immune response and clinical outcome of Bordetella pertussis infection.

Características y beneficios

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Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable