SAB4504246
Anti-phospho-IRAK1 (pThr209) antibody produced in rabbit
affinity isolated antibody
Sinónimos:
Anti-IRAK, Anti-pelle
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Productos recomendados
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
mol peso
76 kDa
reactividad de especies
human
concentración
~1 mg/mL
técnicas
ELISA: 1:40000
western blot: 1:500-1:1000
Nº de acceso NCBI
Nº de acceso UniProt
aplicaciones
research pathology
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
phosphorylation (pThr209)
Información sobre el gen
human ... IRAK1(3654)
Descripción general
Interleukin 1 receptor associated kinase 1 (IRAK1) is a serine/threonine kinase encoded by the gene with 14 exons mapped to human chromosome xq28. The encoded protein belongs to the IRAK family. IRAK1is characterized with a death domain at its N-terminal end which is involved in protein interaction.
Inmunógeno
The antiserum was produced against synthesized peptide derived from human IRAK1 around the phosphorylation site of Thr209.
Immunogen Range: 175-224
Immunogen Range: 175-224
Aplicación
Anti-phospho-IRAK1 (pThr209) antibody produced in rabbit has been used in immunoprecipitation assay.
Acciones bioquímicas o fisiológicas
Interleukin 1 receptor associated kinase 1 (IRAK1) is a vital element of the interleukin-1 receptor (IL-1R) signaling pathway. IRAK1 functions as a downstream effector molecule of the toll like receptor (TLR) signaling pathway, implicated in inflammation, autoimmunity and cancer. IRAK1 is associated with systemic lupus erythematosus (SLE) and it is overexpressed in various cancer types including lung cancer. IRAK1, is considered to be a potential therapeutic target in myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), triple-negative breast cancer (TNBC) metastasis and paclitaxel resistance. Increased expression of IRAK1 leads to head and neck squamous cell carcinomas (HNSCCs). Therefore, inhibition of IRAK1 might be a new therapeutic strategy in HNSCC.
Características y beneficios
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Forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
Lot/Batch Number
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Xiuling Zhang et al.
International journal of clinical and experimental pathology, 7(11), 8096-8104 (2015-01-01)
The interleukin-1 receptor associated kinases 1 (IRAK1) is a down stream effector molecule of the toll like receptor (TLR) signaling pathway, which is involved in inflammation, autoimmunity and cancer. However, the role of IRAK1 in lung cancer remains unclarified. Herein
IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival.
Allie K Adams et al.
Oncotarget, 6(41), 43395-43407 (2015-11-04)
The chromatin-binding DEK protein was recently reported to promote the growth of HPV+ and HPV- head and neck squamous cell carcinomas (HNSCCs). Relevant cellular and molecular mechanism(s) controlled by DEK in HNSCC remain poorly understood. While DEK is known to
Yosuke Tanaka et al.
Nature communications, 13(1), 271-271 (2022-01-14)
Leukemia stem cells (LSCs) in chronic myeloid leukemia (CML) are quiescent, insensitive to BCR-ABL1 tyrosine kinase inhibitors (TKIs) and responsible for CML relapse. Therefore, eradicating quiescent CML LSCs is a major goal in CML therapy. Here, using a G0 marker
Devram S Ghorpade et al.
Nature, 555(7698), 673-677 (2018-03-22)
Obesity-induced metabolic disease involves functional integration among several organs via circulating factors, but little is known about crosstalk between liver and visceral adipose tissue (VAT). In obesity, VAT becomes populated with inflammatory adipose tissue macrophages (ATMs). In obese humans, there
Detlef Neumann et al.
Biochemical and biophysical research communications, 354(4), 1089-1094 (2007-02-06)
Ligand binding in the Toll-like/interleukin-1 receptor family results in the recruitment of an intracellular signaling complex. IRAK-1, which is centrally involved in this complex, is able to homo-oligomerize and to bind to Tollip and the adapters MyD88 and IRAK-4. The
Global Trade Item Number
| Número de referencia del producto (SKU) | GTIN |
|---|---|
| SAB4504246-100UG | 4061832524597 |
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