SAB4502887

Anti-AURA antibody produced in rabbit

affinity isolated antibody

• Sinónimos: AIK, ARK1, Aurora-A, Aurora-family kinase 1, Aurora-related kinase 1
• Código UNSPSC: 12352203
• NACRES: NA.43

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: antigen 45 kDa
• reactividad de especies: mouse, rat, human
• concentración: ~1 mg/mL
• técnicas: ELISA: 1:5000; western blot: 1:500-1:1000
• Nº de acceso NCBI: O14965
• Nº de acceso UniProt: O14965
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... AURKA(6790)

Descripción

Descripción general

AURA/AURKA (aurora kinase A) is mapped on to human chromosome 20q13.2. It is also termed as STK15 (serine/threonine kinase 15). This gene codes for a protein of 403 amino acids with regulatory and catalytic domains.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human AurA.

Immunogen Range: 311-360

Acciones bioquímicas o fisiológicas

AURA/AURKA (aurora kinase A) modulates cell cycle checkpoints and plays important roles in centrosome division, cytoskeleton and cytokinesis. It sustains the integrity of chromosome after DNA damage. The catalytic domain of AURKA possesses a serine/threonine kinase activity role. It is overexpressed in several malignancies like invasive carcinomas of ovary, head, neck and breast.

Características y beneficios

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Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable