SAB4502573

Anti-C-RAF antibody

rabbit polyclonal

• Sinónimos: C-RAF, C-Raf, CRAF, Protein kinase raf 1, kinase Raf1
• Código UNSPSC: 12352203
• NACRES: NA.41
• conjugado: unconjugated
• application: ELISA; IHC; WB
• clon: polyclonal
• reactividad de especies: mouse, human, rat
• citations: 5
• técnicas: ELISA: 1:40000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000

Propiedades

• Nombre del producto: Anti-C-RAF antibody produced in rabbit, affinity isolated antibody
• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: antigen 73 kDa
• reactividad de especies: mouse, human, rat
• concentración: ~1 mg/mL
• técnicas: ELISA: 1:40000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• Nº de acceso NCBI: P04049
• Nº de acceso UniProt: P04049
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... RAF1(5894)

Descripción

Descripción general

Anti-C-RAF Antibody detects endogenous levels of total C-RAF protein.
Raf-1 proto-oncogene, serine/threonine kinase (RAF1) or C-RAF is an anti-apoptotic protein. The gene encoding it is localized on human chromosome 3p25.2.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human C-RAF.

Immunogen Range: 271-320

Acciones bioquímicas o fisiológicas

Raf-1 proto-oncogene, serine/threonine kinase (RAF1) or C-RAF is a crucial component of the Raf/mitogen-activated extracellular signal-regulated kinase (MEK)/extracellular regulated protein kinase (ERK) signaling cascade. It functions as an activator of MEK-1 and -2. The protein is upregulated in many cancers. Mutations in the gene encoding RAF1 have been linked to Noonan syndrome.

Características y beneficios

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Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable