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SAB4502244

Sigma-Aldrich

Anti-CYTL1 antibody produced in rabbit

affinity isolated antibody

Sinónimos:

C4orf4, Cytokine-like protein 1, Protein C17

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen 15 kDa

reactividad de especies

human

concentración

~1 mg/mL

técnicas

ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Nº de acceso NCBI

Q9NRR1

Nº de acceso UniProt

Q9NRR1

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... CYTL1(54360)

Descripción general

Anti-CYTL1 antibody detects endogenous levels of total CYTL1 protein.
The CYTL1 (cytokine like 1) gene is mapped to human chromosome 4p16.2. The gene was first discovered in CD34(+) cells of the bone marrow and cord blood. The encoded protein is predominantly expressed in chondrocytes.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human CYTL1.

Immunogen Range: 61-110

Acciones bioquímicas o fisiológicas

In vitro studies reveal that Cytl1 (cytokine like 1) acts as an autocrine or paracrine regulatory factor in the process of cartilage formation. CYTL1, being homologous with IL-2 (interleukin-2), is considered as a potential cytokine that is involved in regulating immune responses. CYTL1 is known to be associated with the pathogenesis of rheumatoid arthritis and osteoarthritis.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Tanja Vukićević et al.
Journal of the American Society of Nephrology : JASN, 30(5), 795-810 (2019-04-17)
Arginine-vasopressin (AVP) binding to vasopressin V2 receptors promotes redistribution of the water channel aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane of renal collecting duct principal cells. This pathway fine-tunes renal water reabsorption and urinary concentration, and its perturbation
Identification of CCR2-binding features in Cytl1 by a CCL2-like chemokine model.
Tomczak A
Proteins: Structure, Function, and Genetics, 79(4), 1277-1292 (2011)
Cytokine-like 1 Chemoattracts Monocytes/Macrophages via CCR2.
Wang X
Journal of Immunology, 196(10), 4090-4099 (2016)
Yue Tan et al.
Frontiers in immunology, 8, 478-478 (2017-05-10)
The initial infection and transmission of HIV-1 requires C-C chemokine receptor type 5 (CCR5). Here, we report that the membrane-proximal region (MPR, aa 22-38) of CCR5 participates in the infection of HIV-1. First, MPR-specific antibodies elicited in mice dose-dependently inhibited
Xiaolin Wang et al.
Oncoimmunology, 8(5), e1577126-e1577126 (2019-05-10)
CYTL1 is a novel cytokine that was first identified in CD34+ hematopoietic cells. We previously prepared recombinant CYTL1 and verified that it chemoattracted human monocytes via the CCR2/ERK pathway. It has been reported that CYTL1 plays contradictory roles in neuroblastoma
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