SAB4501849

Anti-MDM2 antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Double minute 2 protein, HDM2, Oncoprotein Mdm2, Ubiquitin-protein ligase E3 Mdm2, p53-binding protein Mdm2
• Número MDL: MFCD00282354
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: antigen 55 kDa
• reactividad de especies: human, mouse
• concentración: ~1 mg/mL
• técnicas: ELISA: 1:1000; immunofluorescence: 1:100-1:500; western blot: 1:500-1:1000
• Nº de acceso NCBI: Q00987
• Nº de acceso UniProt: Q00987
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... MDM2(4193)

Descripción

Descripción general

Anti-MDM2 antibody detects endogenous levels of total MDM2 protein.

Murine double minute 2 (MDM2) is an oncogenic protein. It is an E3 ubiquitin-protein ligase, that is mapped to human chromosome 12q15.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human MDM2.

Immunogen Range: 132-181

Aplicación

Anti-MDM2 antibody has been used in immunohistochemistry.

Acciones bioquímicas o fisiológicas

Murine double minute 2 (MDM2) is a negative regulator of the p53 tumor suppressor. It regulates cell cycle, cellular differentiation, cell fate determination, DNA repair and transcription. Epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells are induced by MDM2.

Características y beneficios

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Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable