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Key Documents

SAB4501645

Sigma-Aldrich

Anti-VEGFR2 antibody produced in rabbit

affinity isolated antibody

Sinónimos:

FLK1, KDR, kinase insert domain receptor, protein-tyrosine kinase receptor Flk-1, vascular endothelial growth factor receptor 2

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen 151 kDa

reactividad de especies

mouse, human

concentración

~1 mg/mL

técnicas

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... KDR(3791)

Categorías relacionadas

Descripción general

Anti-VEGFR2 Antibody detects endogenous levels of total VEGFR2 protein.
Vascular endothelial growth factor receptor 2 (VEGFR2), also known as kinase insert domain-containing receptor (KDR), is encoded by the gene mapped to human chromosome 4q12. The encoded protein belongs to the VEGF receptor family.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human VEGFR2.

Immunogen Range: 917-966

Aplicación

Anti-VEGFR2 antibody produced in rabbit has been used in histochemical analysis of hydrogels injected subcutaneously.

Acciones bioquímicas o fisiológicas

Vascular endothelial growth factor receptor 2 (VEGFR2) and its ligand VEGF play a vital role in angiogenesis and inflammation. It also facilitates autocrine stimulation of VEGF. VEGFR2 is implicated in progression of various types of cancers such as gliomas, malignant peripheral nerve sheath tumors, triple-negative breast cancer (TNBC) and gastrointestinal stromal tumors (GISTs).

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Whitney L Stoppel et al.
Journal of biomedical materials research. Part A, 104(12), 3058-3072 (2016-10-28)
Heart failure is the leading cause of death in the United States and rapidly becoming the leading cause of death worldwide. While pharmacological treatments can reduce progression to heart failure following myocardial infarction, there still exists a need for new
Elastic, silk-cardiac extracellular matrix hydrogels exhibit time-dependent stiffening that modulates cardiac fibroblast response
Stoppel WL, et al.
Journal of Biomedical Materials Research Part A, 104(12), 3058-3072 (2016)
Phospholipase C gamma 1 (PLCG1) R707Q mutation is counterselected under targeted therapy in a patient with hepatic angiosarcoma
Prenen H, et al.
Oncotarget, 6(34), 36418-36418 (2015)
Molecular biology of the VEGF and the VEGF receptor family.
Clauss M
Seminars in Thrombosis and Hemostasis, 26, 561-570 (2000)
Increased Gene Copy Number of c-KIT and VEGFR2 at 4q12 in Primary Breast Cancer Is Related to an Aggressive Phenotype and Impaired Prognosis.
Johansson I, et al.
Genes Chromosomes Cancer, 51(4), 375-383 (2012)

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