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Key Documents

SAB4501330

Sigma-Aldrich

Anti-GSK3 antibody produced in rabbit

affinity isolated antibody

Sinónimos:

Factor A, GSK-3 α, GSK3-α, Glycogen synthase kinase-3 α, kinase GSK3-α

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About This Item

Número MDL:
MFCD01633408
Código UNSPSC:
12352203

origen biológico

rabbit

Nivel de calidad

100

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen 50 kDa

reactividad de especies

mouse, human, rat

concentración

~1 mg/mL

técnicas

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Nº de acceso NCBI

P49840

Nº de acceso UniProt

P49840

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... GSK3A(2931)

Descripción general

GSK3A (glycogen synthase kinase 3 α) is a multifunctional protein serine kinase, that is mapped to human chromosome 19q13.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human GSK3 alpha/beta.

Immunogen Range: 246-295

Acciones bioquímicas o fisiológicas

GSK3A (glycogen synthase kinase 3 α) controls multiplication, migration and cell death. It participates in the WNT and PI3K (phosphoinositide 3-kinase) signalling pathways. This protein also modulates glucose levels, inflammation and immune responses.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Population-based linkage analysis of schizophrenia and bipolar case-control cohorts identifies a potential susceptibility locus on 19q13
Francks C, et al.
Molecular Psychiatry, 15(3), 319-325 (2010)
Theodore Lemuel Mathuram et al.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 36(4), 321-344 (2018-02-13)
This study aims to unravel the use of GSK-3 inhibitors as viable apoptotic inducers for teratocarcinoma-derived ovarian PA-1 cells. MTT assay was carried out to assess inhibitory concentrations of LiCl and TDG. AO/EB staining and Hoechst 33258 staining were employed
Vladimirs Pilipenko et al.
European journal of pharmacology, 881, 173290-173290 (2020-06-25)
The earliest hallmarks of sporadic Alzheimer's disease (sAD) are impaired glucose metabolism, chronic neuroinflammation, diminished synaptic plasticity and subsequent cognitive decline. The safest antidiabetic drug metformin has shown both glucose metabolism-improving and cognition-enhancing action in type 2 diabetes patients and
Zhuo Yu et al.
Gut, 63(11), 1793-1804 (2014-01-21)
Androgen receptor (AR) signalling contributes to male predominance in hepatocellular carcinoma (HCC), which is more pronounced in HBV-endemic areas. Cell cycle-related kinase (CCRK) is essential for AR-induced hepatocarcinogenesis but its molecular function in HBV-associated HCC remains obscure. To determine the
Rahul Bhattacharjee et al.
Biology of reproduction, 92(3), 65-65 (2015-01-09)
The signaling enzyme glycogen synthase kinase 3 (GSK3) exists as two isoforms-GSK3A and GSK3B. Protein phosphorylation by GSK3 has important signaling roles in several cells. In our past work, we found that both isoforms of GSK3 are present in mouse

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