SAB4500638

Anti-DDX5 antibody produced in rabbit

affinity isolated antibody

• Sinónimos: DEAD-box protein 5, DEAD-box protein p68, HELR, HLR1, Probable RNA-dependent helicase p68
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: antigen 69 kDa
• reactividad de especies: mouse, rat, human
• concentración: ~1 mg/mL
• técnicas: ELISA: 1:1000; immunofluorescence: 1:100-1:500
• Nº de acceso NCBI: P17844
• Nº de acceso UniProt: P17844
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... DDX5(1655)

Descripción

Descripción general

Anti-DDX5 Antibody detects endogenous levels of total DDX5 protein.

DDX5 (DEAD, Asp-Glu-Ala-Asp, box helicase 5) is a multifunctional protein belonging to the DEAD box family of RNA helicases. It consists of twelve conserved motifs (including the signature D-E-A-D motif) forming a conserved ′helicase′ central domain, which plays an important role in the RNA metabolism.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human DDX5/DEAD-box Protein 5.

Immunogen Range: 565-614

Aplicación

Anti-DDX5, C-Terminal antibody produced in rabbit is suitable for indirect immunofluorescence and indirect ELISA.

Acciones bioquímicas o fisiológicas

DDX5 (DEAD, Asp-Glu-Ala-Asp, box helicase 5) is associated with the regulation of pre-mRNA splicing mechanism. It acts as a transcriptional coactivator to control alternative splicing during the formation of spliceosome. DDX5 provides stability to the RNA secondary structure during several activities such as in the translation initiation, nuclear and mitochondrial splicing. It facilitates the unwinding as well as detachment of protein part from RNA. The protein also participates in the estrogen- and androgen-signaling pathway.

Características y beneficios

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Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable