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Key Documents

SAB4500620

Sigma-Aldrich

Anti-DAPK1 antibody produced in rabbit

affinity isolated antibody

Sinónimos:

DAP kinase 1, DAPK, Death associated protein kinase, kinase DAPK1

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen 160 kDa

reactividad de especies

mouse, human

concentración

~1 mg/mL

técnicas

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... DAPK1(1612)

Descripción general

Anti-DAPK1 Antibody detects endogenous levels of total DAPK1 protein.
Death associated protein kinase 1 (DAPK1) is a calcium/calmodulin–regulated (CaM-regulated) protein kinase that belongs to the kinases family. The protein structure contains a kinase domain, a CaM binding domain, eight ankyrin repeats, and a death domain. DAPK1 protein is encoded by the gene mapped to human chromosome 9q21.33. Anti-DAPK1 antibody detects endogenous levels of total DAPK1 protein.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human DAPK1.

Immunogen Range: 274-323

Aplicación

Anti-DAPK1 antibody produced in rabbit has been used in:
  • immunohistochemistry(1:400 )
  • coimmunoprecipitation
  • immunoblot

Acciones bioquímicas o fisiológicas

Death associated protein kinase 1 (DAPK1) acts as a death-inducing factor in response to interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and transforming growth factor (TGF)-β. It also induces autophagy, proliferation, and immune response to inflammatory signals. DAPK1 promotes the growth of p53-mutant cancers, including pancreatic and ovarian cancers. Therefore, downregulation of DAPK1 can be a potential therapeutic strategy for treating P53 mutant cancers. Overexpression of DAPK1 protein has been observed in Alzheimer′s disease (AD) patients.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Asia Asiaf et al.
Asian Pacific journal of cancer prevention : APJCP, 20(3), 839-848 (2019-03-27)
Aims: Death-associated protein kinase-1 (DAPK1) is a pro-apoptotic Ser/Thr kinase that participates in cell apoptosis and tumor suppression. DAPK1 is frequently lost in many different tumor types including breast cancer. The aim of this study was to evaluate the promoter
Jing Zhang et al.
Cellular & molecular immunology, 11(3), 245-252 (2014-02-18)
Interferon regulatory factor (IRF) 7 has been demonstrated to be a master regulator of virus-induced type I interferon production (IFN), and it plays a central role in the innate immune response against viruses. Here, we identified death-associated protein kinase 1
Craig Stevens et al.
The Journal of biological chemistry, 284(1), 334-344 (2008-11-01)
Death-associated protein kinase (DAPK) is a multidomain enzyme that plays a central role in autophagic and apoptotic signaling, although the protein-protein interactions regulating DAPK functions are not well defined. Peptide aptamer libraries were used to identify the tumor suppressor protein
Jing Zhao et al.
The Journal of clinical investigation, 125(7), 2707-2720 (2015-06-16)
Estrogen receptor-negative (ER-negative) breast cancers are extremely aggressive and associated with poor prognosis. In particular, effective treatment strategies are limited for patients diagnosed with triple receptor-negative breast cancer (TNBC), which also carries the worst prognosis of all forms of breast

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