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Key Documents

SAB4500156

Sigma-Aldrich

Anti-PLK2 antibody produced in rabbit

affinity isolated antibody

Sinónimos:

PLK-2, Polo-like kinase 1, Serine/threonine-protein kinase SNK, Serum-inducible kinase

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

100

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen 78 kDa

reactividad de especies

rat, human, mouse

concentración

~1 mg/mL

técnicas

ELISA: 1:40000
western blot: 1:500-1:1000

Nº de acceso NCBI

Q9NYY3

Nº de acceso UniProt

Q9NYY3

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... PLK2(10769)

Descripción general

Anti-PLK2 Antibody detects endogenous levels of total PLK2 protein.
Polo-like kinases 2 (PLK2) is a member of the serine-threonine kinases family. The PLK2 gene is mapped to human chromosome 5q11.2. PLK2 comprises a C-terminal polo-box domain (PBD) devoid of catalytic activity and an N-terminal kinase domain.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human PLK2.

Immunogen Range: 291-340

Aplicación

Anti-PLK2 antibody produced in rabbit has been used in western blotting(1:1000) (1:5000)

Acciones bioquímicas o fisiológicas

Polo-like kinase 2 (PLK2) participates in regulating centriole duplication, cell death, and cell cycle. It also mediates the spine-associated RapGAP (SPAR) degradation via the ubiquitin-proteasome pathway, thereby regulating synaptic plasticity. Mutations in the PLK2 gene are observed in colorectal cancers. The PLK2 gene knockdown leads to defects in centriole duplication.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Zhiqiang Gao et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 99(4), 403-413 (2020-12-03)
Neuronal injury induced by cerebral ischemia poses a serious health risk globally, and there is no effective clinical therapy. This study was performed to investigate the role of transcription factor AP-2 alpha (TFAP2A) in cerebral ischemia, and the underlying mechanisms
Frameshift mutation and loss of expression of PLK2, a serine/threonine kinase-encoding gene, in colorectal cancers.
Ju Hwa Lee et al.
Pathology, research and practice, 213(8), 1019-1020 (2017-07-13)
Ju Hee Kim et al.
Proteins, 83(7), 1201-1208 (2015-04-08)
Polo-like kinases (Plks) are the key regulators of cell cycle progression, the members of which share a kinase domain and a polo-box domain (PBD) that serves as a protein-binding module. While Plk1 is a promising target for antitumor therapy, Plk2
Michika Mochizuki et al.
Journal of the American Heart Association, 6(10) (2017-10-27)
Recent studies suggest that adult cardiac progenitor cells (CPCs) can produce new cardiac cells. Such cell formation requires an intricate coordination of progenitor cell proliferation and commitment, but the molecular cues responsible for this regulation in CPCs are ill defined.

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