SAB4301167
Anti-MTFP1 antibody produced in rabbit
affinity isolated antibody
Sinónimos:
HSPC242, MTP18
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
clon:
polyclonal
application:
IHC
WB
WB
reactividad de especies:
human, mouse
técnicas:
immunohistochemistry: 1:50- 1:200
western blot: 1:500-1:2000 (Cell Lysate)
western blot: 1:500-1:2000 (Cell Lysate)
citations:
5
Productos recomendados
origen biológico
rabbit
Nivel de calidad
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
mol peso
18 kDa
reactividad de especies
human, mouse
concentración
1.8 mg/mL
técnicas
immunohistochemistry: 1:50- 1:200
western blot: 1:500-1:2000 (Cell Lysate)
isotipo
IgG
nº de acceso
NP_001003704.1
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... MTFP1(51537)
Descripción general
Mitochondrial fission process 1/mitochondrial 18 kDa protein (MTFP1/MTP18), a nuclear-encoded integral protein, is located in the mitochondria. It is also a phosphatidylinositol 3-kinase-dependent protein. MTP18 comprises three α-helical stretches or transmembrane (TM) domains of high hydrophobicity. The MTFP1 gene is located on human chromosome 22q12.2.
Especificidad
The antibody detects endogenous levels of total MTFP1 protein.
Inmunógeno
Fusion protein corresponding to a region derived from internal residues of human mitochondrial fission process 1
Aplicación
Anti-MTFP1 antibody produced in rabbit has been used in western blot (1:1000).
Acciones bioquímicas o fisiológicas
Mitochondrial fission process 1/mitochondrial 18 kDa protein (MTFP1/MTP18) controls mitochondrial fission Hence it helps to maintain the morphology of the mitochondria. Overexpression of MTP18 can facilitate fragmentation of the mitochondria. Loss-of-function of MTFP1 protein promotes cell death. It is crucial for cell viability.
Características y beneficios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forma física
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
Lot/Batch Number
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Aleix Prat et al.
Breast cancer research and treatment, 147(1), 185-191 (2014-07-23)
BRCA1-mutated breast cancer is associated with basal-like disease; however, it is currently unclear if the presence of a BRCA1 mutation depicts a different entity within this subgroup. In this study, we compared the molecular features among basal-like tumors with and
Daniel Tondera et al.
Journal of cell science, 118(Pt 14), 3049-3059 (2005-06-30)
Mitochondria are dynamic organelles that change morphology by controlled fission and fusion events. Mitochondrial fission is regulated by a conserved protein complex assembled at the outer membrane. Human MTP18 is a novel nuclear-encoded mitochondrial membrane protein, implicated in controlling mitochondrial
MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production.
Tingying Xiao et al.
Cell biology international, 44(3), 821-829 (2019-12-10)
Mitochondrial fission process 1 (MTFP1) is a novel nuclear-encoded protein that promotes mitochondrial fission. Increasing lines of evidence indicate that increased mitochondrial fission is involved in carcinogenesis and tumor progression. However, the expression and biological effects of MTFP1 in cancer
Mitochondrial protein 18 is a positive apoptotic regulator in cardiomyocytes under oxidative stress.
Lynn H H Aung et al.
Clinical science (London, England : 1979), 133(9), 1067-1084 (2019-04-25)
Accumulation of reactive oxygen species is a common phenomenon in cardiac stress conditions, for instance, coronary artery disease, aging-related cardiovascular abnormalities, and exposure to cardiac stressors such as hydrogen peroxide (H2O2). Mitochondrial protein 18 (Mtp18) is a novel mitochondrial inner
Arne Jahn et al.
EMBO reports, 18(6), 929-946 (2017-05-14)
Telomeres constitute the ends of linear chromosomes and together with the shelterin complex form a structure essential for genome maintenance and stability. In addition to the constitutive binding of the shelterin complex, other direct, yet more transient interactions are mediated
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