SAB4300606
Anti-LYVE1 antibody produced in rabbit
affinity isolated antibody
Sinónimos:
Anti-CRSBP-1 antibody produced in rabbit, Anti-HAR antibody produced in rabbit, Anti-LYVE-1 antibody produced in rabbit, Anti-XLKD1 antibody produced in rabbit, Anti-lymphatic vessel endothelial hyaluronan receptor 1 antibody produced in rabbit
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Productos recomendados
origen biológico
rabbit
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
formulario
buffered aqueous solution
mol peso
~40 kDa
reactividad de especies
mouse, human, rat
concentración
1 mg/mL
técnicas
western blot: 1:500-1:1000
isotipo
IgG
secuencia del inmunógeno
(K-N-Q-Q-K)
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... LYVE1(10894)
Descripción general
LYVE-1 (lymphatic vessel endothelial hyaluronan receptor 1) is a type I integral membrane polypeptide. It is present on lymph vessel endothelial cells of both normal and neoplastic tissues. LYVE consists of a single N-terminal HA binding domain. It is mapped to human chromosome 11p15.
Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), also known as CRSBP, is encoded by the gene localized on human chromosome 11p15.4. The encoded protein is mainly mapped to the plasma membrane as well as intracellular fibrillar structures in lymphatic endothelial cells (LECs), including primary human dermal LECs and SVEC4-10 cells. LYVE1 belongs to the link module superfamily of C-type lectins.
Inmunógeno
Peptide sequence around aa. 271-275 (K-N-Q-Q-K), according to the protein LYVE1.
Acciones bioquímicas o fisiológicas
LYVE-1 (lymphatic vessel endothelial hyaluronan receptor 1) plays an important role in hyaluronan homeostasis. It controls cellular trafficking of the lymph nodes. It serves as an important lymphatic vessel marker.
Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1) induces activation of its ligand, platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF)-A and hyaluronic acid, opens lymphatic intercellular junctions in vitro and in vivo by enhancing contraction of lymphatic endothelial cells (LECs). The encoded protein also facilitates uptake of hyaluronan (HA) and trafficking of leukocytes to draining lymph nodes.
Características y beneficios
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Descripción de destino
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
Forma física
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
High LYVE-1-positive lymphatic vessel numbers are associated with poor outcome in breast cancer
Bono P, et al.
Clinical Cancer Research, 10(21), 7144-7149 (2004)
Homodimerization of the Lymph Vessel Endothelial Receptor LYVE-1 through a Redox-labile Disulfide Is Critical for Hyaluronan Binding in Lymphatic Endothelium
Banerji S, et al.
The Journal of Biological Chemistry, 291(48), 25004-25018 (2016)
LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan
Banerji S, et al.
The Journal of Cell Biology, 144(4), 789-801 (1999)
Identification of a three-gene expression signature of poor-prognosis breast carcinoma
Bieche I, et al.
Molecular Cancer, 3(1), 37-37 (2004)
Romain Parent et al.
Biochemical and biophysical research communications, 450(1), 7-12 (2014-05-24)
The endothelium lines blood and lymph vessels and protects underlying tissues against external agents such as viruses, bacteria and parasites. Yet, microbes and particularly viruses have developed sophisticated ways to bypass the endothelium in order to gain access to inner
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