SAB4300028

Anti-phospho-MEF2A (pThr³¹²) antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Anti-ADCAD1 antibody produced in rabbit, Anti-RSRFC4 antibody produced in rabbit, Anti-RSRFC9 antibody produced in rabbit, Anti-myocyte enhancer factor 2A antibody produced in rabbit
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: ~54 kDa
• reactividad de especies: human, rat, mouse
• concentración: 1 mg/mL
• técnicas: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200
• isotipo: IgG
• secuencia del inmunógeno: (L-A-TP-P-V)
• Nº de acceso NCBI: NP_001124398.1
• Nº de acceso UniProt: Q02078
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: phosphorylation (pThr312)
• Información sobre el gen: human ... MEF2A(4205)

Descripción

Inmunógeno

Peptide sequence around phosphorylation site of threonine 312 (L-A-T(p)-P-V), according to the protein MEF2A.

Características y beneficios

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Descripción de destino

The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are one class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain.

Forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable