SAB4200471

Anti-SND1 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Sinónimos: Anti-TDRD11, Anti-staphylococcal nuclease and tudor domain containing 1, p100
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: antigen ~102 kDa
• reactividad de especies: rat, mouse, human
• concentración: ~1.0 mg/mL
• técnicas: immunoprecipitation (IP): 1-2 μg using lysates of rat NRK cells.; indirect immunofluorescence: 2.5-5.0 μg/mL using human HeLa cells; western blot: 0.25-0.5 μg/mL using whole extracts of mouse NIH-3T3 cells.
• Nº de acceso UniProt: Q7KZF4
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... SND1(27044) ; mouse ... Snd1(56463) ; rat ... Snd1(64635)

Descripción

Descripción general

Staphylococcal nuclease and tudor domain containing 1 (SND1) protein contains five staphylococcal nuclease-like domains and a tudor-like domain. SND1 is a component of the RNA-induced silencing complex (RISC). This gene is highly conserved from yeast to human.

Inmunógeno

peptide corresponding to the C-terminal region of human SND1 (GeneID: 27044), conjugated to KLH. The corresponding sequence is identical in mouse and rat.

Aplicación

Anti-SND1 (C-terminal) antibody produced in rabbit has been used in immunoblotting, immunoprecipitation and immunofluorescence.

Acciones bioquímicas o fisiológicas

Staphylococcal nuclease and tudor domain containing 1 (SND1) has been shown to be involved in the regulation of transcription and RNA biogenesis. It is known to interact with nucleic acids and proteins. SND1 promotes the breakdown of hyper-edited inosine-containing miRNA precursors. It modulates miRNA transcription and translation through RNA editing by ADAR (adenosine deaminase acting on RNA). Increased SND1 expression is seen in human colon cancer tissues and cell lines.

Forma física

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable