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Merck

SAB4200398

Sigma-Aldrich

Anti-TFRC antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

Sinónimos:

Anti-CD71, Anti-TFR, Anti-TFR1, Anti-TR, Anti-TRFR, Anti-Transferrin receptor (p90, CD71), Anti-Transferrin receptor protein 1, Anti-p90, AntiT9

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen ~90 kDa

reactividad de especies

mouse, rat, human

concentración

~1.0 mg/mL

técnicas

indirect immunofluorescence: 10-20 μg/mL using rat NRK cells
western blot: 2.5-5.0 μg/mL using whole extracts of human U-2-OS and mouse Neuro-2a cells

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... TFRC(7037)
mouse ... Tfrc(22042)
rat ... Tfrc(64678)

Descripción general

Transferrin receptor (TFRC), also known as p90, CD71, TFR and TFR1, is a transmembrane glycoprotein. It is composed of two disulphide-bonded sub-units, contains three N-linked glycan units and is post-translationally modified with phosphate and fatty acyl groups.

Inmunógeno

synthetic peptide corresponding to an internal sequence of human TFRC, conjugated to KLH

Aplicación

Anti-TFRC antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Acciones bioquímicas o fisiológicas

Transferrin receptor (TFRC) mediates cellular iron uptake. It binds iron bound transferrin on the cell surface, and the receptor ligand complex undergoes endocytosis via clathrin coated pits. Endosomal acidification leads to iron release, which is transported to the cytosol or to the mitochondria in erythroid cells. The apotransferrin receptor complex is then recycled to the cell surface, where the affinity of apotransferrin for TFRC drops, resulting in its dissociation. TFRC is necessary for development of erythrocytes and the nervous system.

Forma física

solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Regulation of cellular iron metabolism
Wang J and Pantopoulos K
The Biochemical Journal, 434(3), 365-381 (2011)
Transferrin receptor gene and protein expression and localization in human IUGR and normal term placentas
Mando C, et al.
Placenta, 32(1), 44-50 (2011)
1.6 Mb deletion in chromosome band 3q29 associated with eye abnormalities
Tyshchenko N, et al.
European Journal of Medical Genetics, 52(2-3), 128-130 (2009)
Divya Teja Dondapati et al.
Membranes, 11(12) (2021-12-24)
The cellular prion protein (PrPC) is renowned for its infectious conformational isoform PrPSc, capable of templating subsequent conversions of healthy PrPCs and thus triggering the group of incurable diseases known as transmissible spongiform encephalopathies. Besides this mechanism not being fully
Peina Wang et al.
Cell death & disease, 12(5), 447-447 (2021-05-07)
Ischaemic stroke is becoming the most common cerebral disease in aging populations, but the underlying molecular mechanism of the disease has not yet been fully elucidated. Increasing evidence has indicated that an excess of iron contributes to brain damage in

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