SAB4200102

Anti-AS160 (C-terminal) antibody produced in rabbit

~1.5 mg/mL

• Sinónimos: Anti-Akt substrate of 160 kDa, Anti-TBC1D4 (TBC1 domain family, member 4)
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• mol peso: antigen ~160 kDa
• reactividad de especies: human
• envase: antibody small pack of 25 μL
• validación mejorada: recombinant expression; Learn more about Antibody Enhanced Validation
• concentración: ~1.5 mg/mL
• técnicas: western blot: 0.8-1.6 μg/mL using extracts of HEK-293T cells overexpressing human AS160
• Nº de acceso UniProt: O60343
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... TBC1D4(9882)

Descripción

Descripción general

AS160 is a protein kinase B (Akt) substrate of 160 kDa, also known as TBC1D4. This gene is mapped to human chromosome 13q22.2 and encodes a Rab guanosine triphosphatase (GTPase)-activating protein (RabGAP). It has a number of insulin-regulatable protein kinase B (AKT) phosphomotifs. AS160 is expressed in many differentiated tissues such as adipocytes and skeletal muscles.

Aplicación

Anti-AS160 (C-terminal) antibody produced in rabbit has been used in immunoblotting.

Acciones bioquímicas o fisiológicas

AS160 (protein kinase B (Akt) substrate) is known to play an inhibitory role in the transport of glucose transporter 4 (GLUT4) vesicles. AS160 is associated with GLUT4 vesicles in basal states and dissociates in response to insulin. Reduced expression of AS160 in adipocytes has been shown to increase plasma membrane levels of GLUT4 in an insulin-dependent manner.

Forma física

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable