SAB3501240

Anti-Integrin alpha 4 antibody produced in rabbit

affinity isolated antibody

• Código UNSPSC: 12352203
• NACRES: NA.43

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: liquid
• reactividad de especies: mouse, human, rat
• concentración: 1 mg/mL
• técnicas: immunofluorescence: suitable; western blot: suitable
• isotipo: IgG
• Nº de acceso NCBI: NP_000876
• Nº de acceso UniProt: P13612
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... ITGA4(3676)

Descripción

Descripción general

Integrin alpha 4 Antibody: The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta1, the gut mucosal homing receptor for peripheral T cells.

Inmunógeno

Integrin alpha 4 antibody was raised against a 16 amino acid synthetic peptide from near the center of human Integrin alpha 4.The immunogen is located within amino acids 150 - 200 of Integrin alpha 4.

Aplicación

Integrin alpha 4 antibody can be used for the detection of Integrin alpha 4 by Western blot at 1 μg/mL. Antibody can also be used for immunoflourescence starting at 2 μg/mL. Antibody validated: Immunofluorescence in human samples. All other applications and species not yet tested.

Forma física

Supplied in PBS containing 0.02% sodium azide.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable