SAB3500209
Anti-AGTR1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Sinónimos:
Anti-AT1, Anti-AT1R, Anti-Ang II, Anti-Angiotensin II receptor type 1
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About This Item
Productos recomendados
origen biológico
rabbit
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
reactividad de especies
rat, human, mouse
técnicas
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... AGTR1(185)
Descripción general
Angiotensin II receptor, type 1 (AGTR1) is a G-protein coupled receptor possessing seven transmembrane functional domains. AGTR1 gene spanning around 45.1kb, with five exons, is located on human chromosome 3q21−q25. AGTR1 is highly expressed on endothelial cells, monocytes, podocytes, renal vascular smooth muscle cells and renal arteries.
Angiotensin II receptor, type 1 or AT1 receptor (AGRR1, AT1R) is a receptor for the vasoconstriction peptide angiotensin II involved in the regulation of cardiovascular effects such as blood vasoconstriction (blood pressure), aldosterone and vasopressin secretion, cardiac hypertrophy, vascular smooth muscle cells proliferation, decreased renal blood flow, renal renin inhibition, renal tubular sodium reuptake, modulation of central sympathetic nervous system activity, cardiac contractility, central osmocontrol and extracellular matrix formation.
Rabbit polyclonal anti-AGTR1 reacts with mouse, human, and rat angiotensin II receptor.
Inmunógeno
AGTR1 antibody was raised against a 16 amino acid peptide from near the center of human AGTR1.
Aplicación
Anti-AGTR1 antibody produced in rabbit has been used in in situ proximity ligation assay (PLA) and immunoblotting.
Rabbit polyclonal anti-AGTR1 is used to tag angiotensin II receptor for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of angiotensin II receptor in the regulation of processes that affect vascular functions such as blood pressure and blood flow.
Acciones bioquímicas o fisiológicas
Angiotensin II receptor, type 1 (AGTR1) has a key function in vascular smooth muscle contraction and maintenance of vasopressor effects by controlling aldosterone secretion. The binding of angiotensin II to AGTR1 contributes to the proliferation of vascular smooth muscle cells by the activation of G protein. The binding also results in the activation of Ca2+ dependent kinases as IP3 (inositol triphosphate) and MAPK (mitogen-activated protein kinases) for the synthesis of proteins and expression of proto-oncogenes, respectively. AGTR1 is associated with high risk of hypertension and cardiovascular diseases.
Características y beneficios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Ligadura / enlace
The action of this antibody can be blocked using blocking peptide SBP3500209.
Forma física
Supplied in PBS with 0.02% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Post-Transcriptional Control of Angiotensin II Type 1 Receptor Regulates Osteosarcoma Cell Death
Zhao Y, et al.
Cellular Physiology and Biochemistry, 45(4), 1581-1589 (2018)
Lipid rafts are required for signal transduction by angiotensin II receptor type 1 in neonatal glomerular mesangial cells
Adebiyi A, et al.
Experimental Cell Research, 324(1), 92-104 (2014)
A Nenicu et al.
Human reproduction (Oxford, England), 29(5), 1011-1024 (2014-03-01)
Is telmisartan effective in the treatment of endometriosis? Combined blockade of angiotensin II type 1 receptor (AT1R) and activation of peroxisome proliferator-activated receptor (PPAR)-γ by telmisartan inhibits vascularization and growth of murine endometriosis-like lesions. AT1R and PPAR-γ are involved in
Association between AGTR1 A1166C polymorphism and the susceptibility to diabetic nephropathy: Evidence from a meta-analysis
Zhuang Y, et al.
Medicine, 97(41) (2018)
Asako Kumagai et al.
Hypertension (Dallas, Tex. : 1979), 78(1), 138-150 (2021-04-13)
[Figure: see text].
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