SAB3500196
Anti-CTRP6 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Sinónimos:
Anti-CTRP6
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Productos recomendados
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
formulario
buffered aqueous solution
reactividad de especies
human, mouse
técnicas
immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... C1QTNF6(114904)
Descripción general
C1q and TNF (Tumour necrosis factor) related protein 6 (CTRP6/C1QTNF6) is a glycoprotein which belongs to family of proteins containing TNF alpha-like globular domain. CTRP6 is a single peptide with a short variable region, a collagen like region, and a C-terminal globular domain. CTRP6 is expressed in human synoviocytes. In human chromosome, the gene is localized on 22q12.3.
Inmunógeno
CTRP6 antibody was raised against a 15 amino acid peptide from near the carboxy-terminus of human CTRP6.
Acciones bioquímicas o fisiológicas
C1q and TNF (Tumour necrosis factor) related protein 6 (CTRP6) plays a major role in fatty acid metabolism. CTRP6 phosphorylates AMCK (5′-AMP (adenosine monophosphate)-activated protein kinase) and ACC (acetyl coenzyme A carboxylase) and activates AMCK-ACC pathway. The expression level of CTRP6 is increased in rheumatoid arthritis. CTRP6 inhibits alternative complement pathway and helps in maintaining pregnancy. CTRP6 mediates the ectopic lipogenesis in myoblasts through AdipoR1/Erk/PPARγ (Adiponectin receptor 1/Extracellular signal-regulated kinases/Peroxisome proliferator-activated receptor gamma) signalling pathway. CTRP6 is overexpressed in hepatocellular carcinoma and stimulates angiogenesis by Akt (serine/threonine-protein kinase) pathway. CTRP6 confers susceptibility to type I diabetes. CTRP6 maybe a key regulator connecting obesity with tissue inflammation and insulin resistance.
Características y beneficios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Ligadura / enlace
The action of this antibody can be blocked using blocking peptide SBP3500196.
Forma física
Supplied in PBS with 0.02% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
C1q/TNF-related protein 6 (CTRP6) links obesity to adipose tissue inflammation and insulin resistance
Lei X, et al.
The Journal of Biological Chemistry, 292(36), 14836-14850 (2017)
Lipogenesis in myoblasts and its regulation of CTRP6 by AdipoR1/Erk/PPAR gamma signalling pathway
Wu W, et al.
Acta biochimica et biophysica Sinica, 48(6), 509-519 (2016)
Expression of a secretory protein C1qTNF6, a C1qTNF family member, in hepatocellular carcinoma
Takeuchi T, et al.
Analytical Cellular Pathology, 34(3), 113-121 (2011)
Masanori A Murayama et al.
Nature communications, 6, 8483-8483 (2015-09-26)
The complement system is important for the host defence against infection as well as for the development of inflammatory diseases. Here we show that C1q/TNF-related protein 6 (CTRP6; gene symbol C1qtnf6) expression is elevated in mouse rheumatoid arthritis (RA) models.
Wan Lee et al.
FEBS letters, 584(5), 968-972 (2010-01-28)
C1qTNF-related proteins (CTRPs) are involved in diverse processes including metabolism, inflammation host defense, apoptosis, cell differentiation, autoimmunity, hibernation, and organogenesis. However, the physiological role of CTRP6 remains poorly understood. Here we demonstrate that the globular domain of CTRP6 mediates the
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