SAB2501188

Anti-LRP4 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-KIAA0816, Anti-LRP10, Anti-MEGF7, low density lipoprotein receptor-related protein 4
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: goat
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• reactividad de especies: human
• técnicas: indirect ELISA: suitable; western blot: suitable
• Nº de acceso UniProt: O75096
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... LRP4(4038)

Descripción

Descripción general

Low density lipoprotein receptor-related protein 4 (LRP4) is expressed on the surface of the postsynaptic membranes. It acts as a receptor for agrin. The protein belongs to the low-density lipoprotein receptor-related proteins (LRPs) family. The LRP4 gene is localized on human chromosome 11p11.2.

Inmunógeno

Peptide with sequence CSNPSYRTSTQEVK , from the internal region of the protein sequence according to NP_002325.2.

Acciones bioquímicas o fisiológicas

LRP4 (Low density lipoprotein receptor-related protein 4) is a multifunctional protein which controls the extracellular cell signaling pathways including Wnt β-catenin signaling. It is highly essential for maintaining the bone mineral density. LRP4 binds to Dkk1 (dickkopf 1) and sclerostin to control the bone growth via Wnt and bone morphogenic protein (BMP) signaling pathways. Clinically, it is highly important for the development of osteoporosis. Mutation in the LRP4 gene causes an autosomal-recessive congenital disorder, Cenani-Lenz syndrome characterized with limb and kidney malformations.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable